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Role of PAX8 in the regulation of MET and RON receptor tyrosine kinases in non-small cell lung cancer

Overview of attention for article published in BMC Cancer, March 2014
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Title
Role of PAX8 in the regulation of MET and RON receptor tyrosine kinases in non-small cell lung cancer
Published in
BMC Cancer, March 2014
DOI 10.1186/1471-2407-14-185
Pubmed ID
Authors

Rajani Kanteti, Essam El-Hashani, Immanuel Dhanasingh, Maria Tretiakova, Aliya N Husain, Sherven Sharma, Jay Sharma, Everett E Vokes, Ravi Salgia

Abstract

Non-small cell lung cancers (NSCLC) are highly heterogeneous at the molecular level and comprise 75% of all lung tumors. We have previously shown that the receptor tyrosine kinase (RTK) MET frequently suffers gain-of-function mutations that significantly promote lung tumorigenesis. Subsequent studies from our lab also revealed that PAX5 transcription factor is preferentially expressed in small cell lung cancer (SCLC) and promotes MET transcription. PAX8, however, is also expressed in NSCLC cell lines. We therefore investigated the role of PAX8 in NSCLC.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 4%
Unknown 23 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 25%
Researcher 6 25%
Student > Master 5 21%
Professor > Associate Professor 3 13%
Other 1 4%
Other 2 8%
Unknown 1 4%
Readers by discipline Count As %
Medicine and Dentistry 7 29%
Biochemistry, Genetics and Molecular Biology 6 25%
Agricultural and Biological Sciences 4 17%
Pharmacology, Toxicology and Pharmaceutical Science 1 4%
Unspecified 1 4%
Other 3 13%
Unknown 2 8%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 November 2014.
All research outputs
#18,382,900
of 22,769,322 outputs
Outputs from BMC Cancer
#5,417
of 8,280 outputs
Outputs of similar age
#160,861
of 221,025 outputs
Outputs of similar age from BMC Cancer
#98
of 137 outputs
Altmetric has tracked 22,769,322 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,280 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 221,025 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 137 others from the same source and published within six weeks on either side of this one. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.