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Molecular and cellular neuroinflammatory status of mouse brain after systemic lipopolysaccharide challenge: importance of CCR2/CCL2 signaling

Overview of attention for article published in Journal of Neuroinflammation, July 2014
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Citations

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216 Mendeley
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Title
Molecular and cellular neuroinflammatory status of mouse brain after systemic lipopolysaccharide challenge: importance of CCR2/CCL2 signaling
Published in
Journal of Neuroinflammation, July 2014
DOI 10.1186/1742-2094-11-132
Pubmed ID
Authors

Julie Cazareth, Alice Guyon, Catherine Heurteaux, Joëlle Chabry, Agnès Petit-Paitel

Abstract

Genetic and environmental factors are critical elements influencing the etiology of major depression. It is now accepted that neuroinflammatory processes play a major role in neuropsychological disorders. Neuroinflammation results from the dysregulation of the synthesis and/or release of pro- and anti-inflammatory cytokines with central or peripheral origin after various insults. Systemic bacterial lipopolysaccharide (LPS) challenge is commonly used to study inflammation-induced depressive-like behaviors in rodents. In the present study, we investigated immune-to-brain communication in mice by examining the effects of peripheral LPS injection on neuroinflammation encompassing cytokine and chemokine production, microglia and central nervous system (CNS)-associated phagocyte activation, immune cell infiltration and serotonergic neuronal function.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 216 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Russia 1 <1%
Greece 1 <1%
Unknown 213 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 49 23%
Researcher 37 17%
Student > Master 24 11%
Student > Bachelor 22 10%
Student > Doctoral Student 17 8%
Other 30 14%
Unknown 37 17%
Readers by discipline Count As %
Neuroscience 58 27%
Agricultural and Biological Sciences 39 18%
Medicine and Dentistry 24 11%
Biochemistry, Genetics and Molecular Biology 19 9%
Immunology and Microbiology 8 4%
Other 18 8%
Unknown 50 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 November 2014.
All research outputs
#20,242,136
of 22,769,322 outputs
Outputs from Journal of Neuroinflammation
#2,300
of 2,621 outputs
Outputs of similar age
#192,542
of 228,719 outputs
Outputs of similar age from Journal of Neuroinflammation
#25
of 26 outputs
Altmetric has tracked 22,769,322 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,621 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 228,719 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.