Title |
Molecular and cellular neuroinflammatory status of mouse brain after systemic lipopolysaccharide challenge: importance of CCR2/CCL2 signaling
|
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Published in |
Journal of Neuroinflammation, July 2014
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DOI | 10.1186/1742-2094-11-132 |
Pubmed ID | |
Authors |
Julie Cazareth, Alice Guyon, Catherine Heurteaux, Joëlle Chabry, Agnès Petit-Paitel |
Abstract |
Genetic and environmental factors are critical elements influencing the etiology of major depression. It is now accepted that neuroinflammatory processes play a major role in neuropsychological disorders. Neuroinflammation results from the dysregulation of the synthesis and/or release of pro- and anti-inflammatory cytokines with central or peripheral origin after various insults. Systemic bacterial lipopolysaccharide (LPS) challenge is commonly used to study inflammation-induced depressive-like behaviors in rodents. In the present study, we investigated immune-to-brain communication in mice by examining the effects of peripheral LPS injection on neuroinflammation encompassing cytokine and chemokine production, microglia and central nervous system (CNS)-associated phagocyte activation, immune cell infiltration and serotonergic neuronal function. |
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Russia | 1 | <1% |
Greece | 1 | <1% |
Unknown | 213 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 49 | 23% |
Researcher | 37 | 17% |
Student > Master | 24 | 11% |
Student > Bachelor | 22 | 10% |
Student > Doctoral Student | 17 | 8% |
Other | 30 | 14% |
Unknown | 37 | 17% |
Readers by discipline | Count | As % |
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Neuroscience | 58 | 27% |
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Medicine and Dentistry | 24 | 11% |
Biochemistry, Genetics and Molecular Biology | 19 | 9% |
Immunology and Microbiology | 8 | 4% |
Other | 18 | 8% |
Unknown | 50 | 23% |