Title |
An effective docking strategy for virtual screening based on multi-objective optimization algorithm
|
---|---|
Published in |
BMC Bioinformatics, February 2009
|
DOI | 10.1186/1471-2105-10-58 |
Pubmed ID | |
Authors |
Honglin Li, Hailei Zhang, Mingyue Zheng, Jie Luo, Ling Kang, Xiaofeng Liu, Xicheng Wang, Hualiang Jiang |
Abstract |
Development of a fast and accurate scoring function in virtual screening remains a hot issue in current computer-aided drug research. Different scoring functions focus on diverse aspects of ligand binding, and no single scoring can satisfy the peculiarities of each target system. Therefore, the idea of a consensus score strategy was put forward. Integrating several scoring functions, consensus score re-assesses the docked conformations using a primary scoring function. However, it is not really robust and efficient from the perspective of optimization. Furthermore, to date, the majority of available methods are still based on single objective optimization design. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 3 | 4% |
Brazil | 1 | 1% |
India | 1 | 1% |
Argentina | 1 | 1% |
China | 1 | 1% |
United States | 1 | 1% |
Unknown | 64 | 89% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 20 | 28% |
Researcher | 18 | 25% |
Professor > Associate Professor | 4 | 6% |
Student > Doctoral Student | 4 | 6% |
Student > Master | 4 | 6% |
Other | 12 | 17% |
Unknown | 10 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 13 | 18% |
Chemistry | 11 | 15% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 10% |
Biochemistry, Genetics and Molecular Biology | 7 | 10% |
Computer Science | 7 | 10% |
Other | 13 | 18% |
Unknown | 14 | 19% |