Title |
Blocking and reversing hepatic fibrosis in patients with chronic hepatitis B treated by traditional Chinese medicine (tablets of biejia ruangan or RGT): study protocol for a randomized controlled trial
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Published in |
Trials, November 2014
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DOI | 10.1186/1745-6215-15-438 |
Pubmed ID | |
Authors |
Jianhui Qu, Zujiang Yu, Qin Li, Yongping Chen, Dedong Xiang, Lin Tan, Chunliang Lei, Wenlin Bai, Hongyan Li, Qinghua Shang, Liang Chen, Xiaoyu Hu, Wei Lu, Zhiqin Li, Da Chen, Xiaodong Wang, Changjiang Zhang, Guangming Xiao, Xun Qi, Jing Chen, Li Zhou, Guofeng Chen, Yonggang Li, Zhen Zeng, Guanghua Rong, Zheng Dong, Yan Chen, Min Lou, Chunping Wang, Yinying Lu, Cuihong Zhang, Yongping Yang |
Abstract |
Chronic hepatitis B (CHB) can progress to cirrhosis, hepatocellular carcinoma (HCC) and ultimately liver-related death. Although oral antiviral therapy for patients with CHB reduces the risk of such complications, once cirrhosis is established, the benefits of antiviral therapy are not robustly demonstrated. According to traditional Chinese medicine (TCM), some Chinese herbal medicines promote blood circulation and soften hard masses, and therefore they may block and reverse hepatic fibrosis. The aim of this study is to evaluate the effects of TCM tablets of the compound biejia ruangan (RGT) administered for fibrosis, and entecavir (ETV), on the development of HCC in patients with CHB or hepatitis B virus (HBV)-related compensated cirrhosis. |
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Scientists | 1 | 50% |
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Economics, Econometrics and Finance | 2 | 4% |
Other | 4 | 7% |
Unknown | 27 | 47% |