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Blocking and reversing hepatic fibrosis in patients with chronic hepatitis B treated by traditional Chinese medicine (tablets of biejia ruangan or RGT): study protocol for a randomized controlled…

Overview of attention for article published in Trials, November 2014
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Title
Blocking and reversing hepatic fibrosis in patients with chronic hepatitis B treated by traditional Chinese medicine (tablets of biejia ruangan or RGT): study protocol for a randomized controlled trial
Published in
Trials, November 2014
DOI 10.1186/1745-6215-15-438
Pubmed ID
Authors

Jianhui Qu, Zujiang Yu, Qin Li, Yongping Chen, Dedong Xiang, Lin Tan, Chunliang Lei, Wenlin Bai, Hongyan Li, Qinghua Shang, Liang Chen, Xiaoyu Hu, Wei Lu, Zhiqin Li, Da Chen, Xiaodong Wang, Changjiang Zhang, Guangming Xiao, Xun Qi, Jing Chen, Li Zhou, Guofeng Chen, Yonggang Li, Zhen Zeng, Guanghua Rong, Zheng Dong, Yan Chen, Min Lou, Chunping Wang, Yinying Lu, Cuihong Zhang, Yongping Yang

Abstract

Chronic hepatitis B (CHB) can progress to cirrhosis, hepatocellular carcinoma (HCC) and ultimately liver-related death. Although oral antiviral therapy for patients with CHB reduces the risk of such complications, once cirrhosis is established, the benefits of antiviral therapy are not robustly demonstrated. According to traditional Chinese medicine (TCM), some Chinese herbal medicines promote blood circulation and soften hard masses, and therefore they may block and reverse hepatic fibrosis. The aim of this study is to evaluate the effects of TCM tablets of the compound biejia ruangan (RGT) administered for fibrosis, and entecavir (ETV), on the development of HCC in patients with CHB or hepatitis B virus (HBV)-related compensated cirrhosis.

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Mendeley readers

The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 57 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 7 12%
Researcher 6 11%
Student > Master 5 9%
Other 4 7%
Student > Doctoral Student 3 5%
Other 8 14%
Unknown 24 42%
Readers by discipline Count As %
Medicine and Dentistry 14 25%
Biochemistry, Genetics and Molecular Biology 4 7%
Nursing and Health Professions 4 7%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Economics, Econometrics and Finance 2 4%
Other 4 7%
Unknown 27 47%