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Mendeley readers
Attention Score in Context
| Title |
Size does matter: overcoming the adeno-associated virus packaging limit
|
|---|---|
| Published in |
Respiratory Research, July 2000
|
| DOI | 10.1186/rr6 |
| Pubmed ID | |
| Authors |
Terence R Flotte |
| Abstract |
Recombinant adeno-associated virus (rAAV) vectors mediate long-term gene transfer without any known toxicity. The primary limitation of rAAV has been the small size of the virion (20 nm), which only permits the packaging of 4.7 kilobases (kb) of exogenous DNA, including the promoter, the polyadenylation signal and any other enhancer elements that might be desired. Two recent reports (D Duan et al: Nat Med 2000, 6:595-598; Z Yan et al: Proc Natl Acad Sci USA 2000, 97:6716-6721) have exploited a unique feature of rAAV genomes, their ability to link together in doublets or strings, to bypass this size limitation. This technology could improve the chances for successful gene therapy of diseases like cystic fibrosis or Duchenne muscular dystrophy that lead to significant pulmonary morbidity. |
Mendeley readers
The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 3% |
| Unknown | 68 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 15 | 21% |
| Student > Master | 11 | 16% |
| Student > Ph. D. Student | 10 | 14% |
| Researcher | 6 | 9% |
| Student > Doctoral Student | 2 | 3% |
| Other | 7 | 10% |
| Unknown | 19 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 18 | 26% |
| Biochemistry, Genetics and Molecular Biology | 14 | 20% |
| Neuroscience | 6 | 9% |
| Medicine and Dentistry | 5 | 7% |
| Chemistry | 3 | 4% |
| Other | 5 | 7% |
| Unknown | 19 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 April 2021.
All research outputs
#8,534,528
of 25,373,627 outputs
Outputs from Respiratory Research
#1,153
of 3,062 outputs
Outputs of similar age
#13,210
of 39,186 outputs
Outputs of similar age from Respiratory Research
#3
of 7 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,062 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.9. This one has gotten more attention than average, scoring higher than 56% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 39,186 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.