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Mendeley readers
| Title |
Alterations on peripheral B cell subsets following an acute uncomplicated clinical malaria infection in children
|
|---|---|
| Published in |
Malaria Journal, November 2008
|
| DOI | 10.1186/1475-2875-7-238 |
| Pubmed ID | |
| Authors |
Amolo S Asito, Ann M Moormann, Chelimo Kiprotich, Zipporah W Ng'ang'a, Robert Ploutz-Snyder, Rosemary Rochford |
| Abstract |
The effects of Plasmodium falciparum on B-cell homeostasis have not been well characterized. This study investigated whether an episode of acute malaria in young children results in changes in the peripheral B cell phenotype. Using flow-cytofluorimetric analysis, the B cell phenotypes found in the peripheral blood of children aged 2-5 years were characterized during an episode of acute uncomplicated clinical malaria and four weeks post-recovery and in healthy age-matched controls. There was a significant decrease in CD19+ B lymphocytes during acute malaria. Characterization of the CD19+ B cell subsets in the peripheral blood based on expression of IgD and CD38 revealed a significant decrease in the numbers of naive 1 CD38-IgD+ B cells while there was an increase in CD38+IgD- memory 3 B cells during acute malaria. Further analysis of the peripheral B cell phenotype also identified an expansion of transitional CD10+CD19+ B cells in children following an episode of acute malaria with up to 25% of total CD19+ B cell pool residing in this subset. Children experiencing an episode of acute uncomplicated clinical malaria experienced profound disturbances in B cell homeostasis. |
Mendeley readers
The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 68 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 21 | 31% |
| Researcher | 11 | 16% |
| Student > Bachelor | 6 | 9% |
| Student > Master | 6 | 9% |
| Student > Doctoral Student | 3 | 4% |
| Other | 11 | 16% |
| Unknown | 10 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 24 | 35% |
| Immunology and Microbiology | 12 | 18% |
| Medicine and Dentistry | 9 | 13% |
| Biochemistry, Genetics and Molecular Biology | 6 | 9% |
| Social Sciences | 2 | 3% |
| Other | 4 | 6% |
| Unknown | 11 | 16% |