Title |
Reduced hippocampal and medial prefrontal gray matter mediate the association between reported childhood maltreatment and trait anxiety in adulthood and predict sensitivity to future life stress
|
---|---|
Published in |
Biology of Mood & Anxiety Disorders, November 2014
|
DOI | 10.1186/2045-5380-4-12 |
Pubmed ID | |
Authors |
Adam X Gorka, Jamie L Hanson, Spenser R Radtke, Ahmad R Hariri |
Abstract |
The experience of early life stress is a consistently identified risk factor for the development of mood and anxiety disorders. Preclinical research employing animal models of early life stress has made inroads in understanding this association and suggests that the negative sequelae of early life stress may be mediated by developmental disruption of corticolimbic structures supporting stress responsiveness. Work in humans has corroborated this idea, as childhood adversity has been associated with alterations in gray matter volumes of the hippocampus, amygdala, and medial prefrontal cortex. Yet, missing from this body of research is a full understanding of how these neurobiological vulnerabilities may mechanistically contribute to the reported link between adverse childhood experiences and later affective psychopathology. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 75% |
Scientists | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | <1% |
Switzerland | 1 | <1% |
United Kingdom | 1 | <1% |
Mexico | 1 | <1% |
United States | 1 | <1% |
Poland | 1 | <1% |
Unknown | 207 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 38 | 18% |
Researcher | 36 | 17% |
Student > Bachelor | 22 | 10% |
Student > Master | 21 | 10% |
Student > Doctoral Student | 18 | 8% |
Other | 30 | 14% |
Unknown | 48 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 61 | 29% |
Neuroscience | 35 | 16% |
Medicine and Dentistry | 26 | 12% |
Agricultural and Biological Sciences | 11 | 5% |
Philosophy | 3 | 1% |
Other | 17 | 8% |
Unknown | 60 | 28% |