Title |
A pilot three-month sitagliptin treatment increases serum adiponectin level in Japanese patients with type 2 diabetes mellitus- a randomized controlled trial START-J study
|
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Published in |
Cardiovascular Diabetology, May 2014
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DOI | 10.1186/1475-2840-13-96 |
Pubmed ID | |
Authors |
Toshiyuki Hibuse, Norikazu Maeda, Ken Kishida, Takekazu Kimura, Tomoko Minami, Eriko Takeshita, Ayumu Hirata, Yasuhiko Nakagawa, Susumu Kashine, Akemi Oka, Masumi Hayashi, Hitoshi Nishizawa, Tohru Funahashi, Iichiro Shimomura |
Abstract |
The dipeptidyl-peptidase-IV (DPP-4) inhibitors, including sitagliptin, are used for the treatment of type 2 diabetes mellitus (T2DM). Adiponectin, an adipocyte-derived circulating protein, has anti-atherosclerotic and anti-diabetic properties and is effectively elevated in bloodstream by thiazolidinediones, an insulin sensitizer. However, the effect of sitagliptin treatment on serum adiponectin level in T2DM has not fully elucidated in Japanese T2DM patients. The aim of the present study was to examine the effect of sitagliptin treatment on serum adiponectin levels in T2DM subjects. |
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Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 18 | 24% |
Student > Master | 12 | 16% |
Other | 8 | 11% |
Researcher | 5 | 7% |
Student > Ph. D. Student | 4 | 5% |
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Unknown | 21 | 28% |
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