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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Digitoxin and its analogs as novel cancer therapeutics
|
|---|---|
| Published in |
Experimental Hematology & Oncology, April 2012
|
| DOI | 10.1186/2162-3619-1-4 |
| Pubmed ID | |
| Authors |
Hosam A Elbaz, Todd A Stueckle, William Tse, Yon Rojanasakul, Cerasela Zoica Dinu |
| Abstract |
A growing body of evidence indicates that digitoxin cardiac glycoside is a promising anticancer agent when used at therapeutic concentrations. Digitoxin has a prolonged half-life and a well-established clinical profile. New scientific avenues have shown that manipulating the chemical structure of the saccharide moiety of digitoxin leads to synthetic analogs with increased cytotoxic activity. However, the anticancer mechanism of digitoxin or synthetic analogs is still subject to study while concerns about digitoxin's cardiotoxicity preclude its clinical application in cancer therapeutics. This review focuses on digitoxin and its analogs, and their cytotoxicity against cancer cells. Moreover, a new perspective on the pharmacological aspects of digitoxin and its analogs is provided to emphasize new research directions for developing potent chemotherapeutic drugs. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 115 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Unknown | 114 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 23 | 20% |
| Researcher | 21 | 18% |
| Student > Ph. D. Student | 19 | 17% |
| Student > Master | 10 | 9% |
| Professor > Associate Professor | 7 | 6% |
| Other | 16 | 14% |
| Unknown | 19 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 18 | 16% |
| Agricultural and Biological Sciences | 17 | 15% |
| Pharmacology, Toxicology and Pharmaceutical Science | 17 | 15% |
| Chemistry | 16 | 14% |
| Medicine and Dentistry | 15 | 13% |
| Other | 12 | 10% |
| Unknown | 20 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 January 2023.
All research outputs
#3,828,453
of 25,525,181 outputs
Outputs from Experimental Hematology & Oncology
#42
of 372 outputs
Outputs of similar age
#23,779
of 173,851 outputs
Outputs of similar age from Experimental Hematology & Oncology
#1
of 5 outputs
Altmetric has tracked 25,525,181 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 372 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.9. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 173,851 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them