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Microglial activation occurs in the absence of anxiety-like behavior following microembolic stroke in female, but not male, rats

Overview of attention for article published in Journal of Neuroinflammation, November 2014
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Title
Microglial activation occurs in the absence of anxiety-like behavior following microembolic stroke in female, but not male, rats
Published in
Journal of Neuroinflammation, November 2014
DOI 10.1186/s12974-014-0174-7
Pubmed ID
Authors

Christina L Nemeth, Renuka Reddy, Mandakh Bekhbat, Jabari Bailey, Gretchen N Neigh

Abstract

BackgroundThe incidence of depression and anxiety disorders is twice as high in women than men; however, females exhibit less neuronal damage following an equivalent ischemic event. Microembolic stroke increases anxiety- and depressive-like behaviors in male rats but the behavioral repercussions in females are unknown.FindingsGiven the relative neuronal protection from stroke in ovary-intact females, female rats exposed to microembolic stroke may be behaviorally protected as compared to males. The data presented demonstrate that anxiety-like behavior is increased in males despite a comparable increase in microglial activation following microembolic stroke in both males and females.ConclusionsThese data suggest that males may be more behaviorally susceptible to the effects of microembolic stroke and further illustrate a dissociation between neuroinflammation and behavior in females.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 32 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 19%
Student > Ph. D. Student 6 19%
Professor 3 9%
Student > Doctoral Student 3 9%
Student > Master 3 9%
Other 8 25%
Unknown 3 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 28%
Neuroscience 8 25%
Unspecified 2 6%
Computer Science 2 6%
Biochemistry, Genetics and Molecular Biology 1 3%
Other 6 19%
Unknown 4 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 November 2014.
All research outputs
#20,242,779
of 22,770,070 outputs
Outputs from Journal of Neuroinflammation
#2,300
of 2,621 outputs
Outputs of similar age
#219,232
of 262,795 outputs
Outputs of similar age from Journal of Neuroinflammation
#22
of 30 outputs
Altmetric has tracked 22,770,070 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,621 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.