Title |
Microglial activation occurs in the absence of anxiety-like behavior following microembolic stroke in female, but not male, rats
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Published in |
Journal of Neuroinflammation, November 2014
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DOI | 10.1186/s12974-014-0174-7 |
Pubmed ID | |
Authors |
Christina L Nemeth, Renuka Reddy, Mandakh Bekhbat, Jabari Bailey, Gretchen N Neigh |
Abstract |
BackgroundThe incidence of depression and anxiety disorders is twice as high in women than men; however, females exhibit less neuronal damage following an equivalent ischemic event. Microembolic stroke increases anxiety- and depressive-like behaviors in male rats but the behavioral repercussions in females are unknown.FindingsGiven the relative neuronal protection from stroke in ovary-intact females, female rats exposed to microembolic stroke may be behaviorally protected as compared to males. The data presented demonstrate that anxiety-like behavior is increased in males despite a comparable increase in microglial activation following microembolic stroke in both males and females.ConclusionsThese data suggest that males may be more behaviorally susceptible to the effects of microembolic stroke and further illustrate a dissociation between neuroinflammation and behavior in females. |
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