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The nonstructural proteins of Pneumoviruses are remarkably distinct in substrate diversity and specificity

Overview of attention for article published in Virology Journal, November 2017
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (54th percentile)
  • Good Attention Score compared to outputs of the same age and source (72nd percentile)

Mentioned by

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3 tweeters

Citations

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5 Dimensions

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23 Mendeley
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Title
The nonstructural proteins of Pneumoviruses are remarkably distinct in substrate diversity and specificity
Published in
Virology Journal, November 2017
DOI 10.1186/s12985-017-0881-7
Pubmed ID
Authors

Michael Ribaudo, Sailen Barik

Abstract

Interferon (IFN) inhibits viruses by inducing several hundred cellular genes, aptly named 'interferon (IFN)-stimulated genes' (ISGs). The only two RNA viruses of the Pneumovirus genus of the Paramyxoviridae family, namely Respiratory Syncytial Virus (RSV) and Pneumonia Virus of Mice (PVM), each encode two nonstructural (NS) proteins that share no sequence similarity but yet suppress IFN. Since suppression of IFN underlies the ability of these viruses to replicate in the host cells, the mechanism of such suppression has become an important area of research. This Short Report is an important extension of our previous efforts in defining this mechanism. We show that, like their PVM counterparts, the RSV NS proteins also target multiple members of the ISG family. While significantly extending the substrate repertoire of the RSV NS proteins, these results, unexpectedly, also reveal that the target preferences of the NS proteins of the two viruses are entirely different. This is surprising since the two Pneumoviruses are phylogenetically close with similar genome organization and gene function, and the NS proteins of both also serve as suppressors of host IFN response. The finding that the NS proteins of the two highly similar viruses suppress entirely different members of the ISG family raises intriguing questions of pneumoviral NS evolution and mechanism of action.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 23 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 22%
Student > Bachelor 4 17%
Student > Doctoral Student 2 9%
Student > Master 2 9%
Student > Postgraduate 2 9%
Other 4 17%
Unknown 4 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 22%
Immunology and Microbiology 4 17%
Medicine and Dentistry 3 13%
Chemistry 2 9%
Social Sciences 1 4%
Other 3 13%
Unknown 5 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 July 2018.
All research outputs
#7,440,278
of 13,801,769 outputs
Outputs from Virology Journal
#898
of 2,219 outputs
Outputs of similar age
#137,362
of 313,418 outputs
Outputs of similar age from Virology Journal
#57
of 215 outputs
Altmetric has tracked 13,801,769 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,219 research outputs from this source. They receive a mean Attention Score of 3.5. This one has gotten more attention than average, scoring higher than 56% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,418 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.
We're also able to compare this research output to 215 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.