Title |
The effect on knee-joint load of instruction in analgesic use compared with neuromuscular exercise in patients with knee osteoarthritis: study protocol for a randomized, single-blind, controlled trial (the EXERPHARMA trial)
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Published in |
Trials, November 2014
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DOI | 10.1186/1745-6215-15-444 |
Pubmed ID | |
Authors |
Brian Clausen, Anders Holsgaard-Larsen, Jens Søndergaard, Robin Christensen, Thomas P Andriacchi, Ewa M Roos |
Abstract |
Knee osteoarthritis (OA) is a mechanically driven disease, and it is suggested that medial tibiofemoral knee-joint load increases with pharmacologic pain relief, indicating that pharmacologic pain relief may be positively associated with disease progression. Treatment modalities that can both relieve pain and reduce knee-joint load would be preferable. The knee-joint load is influenced by functional alignment of the trunk, pelvis, and lower-limb segments with respect to the knee, as well as the ground-reaction force generated during movement. Neuromuscular exercise can influence knee load and decrease knee pain. It includes exercises to improve balance, muscle activation, functional alignment, and functional knee stability. The primary objective of this randomized controlled trial (RCT) is to investigate the efficacy of a NEuroMuscular EXercise (NEMEX) therapy program, compared with optimized analgesics and antiinflammatory drug use, on the measures of knee-joint load in people with mild to moderate medial tibiofemoral knee osteoarthritis. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | <1% |
United Kingdom | 1 | <1% |
Unknown | 303 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 43 | 14% |
Student > Bachelor | 38 | 12% |
Student > Ph. D. Student | 29 | 10% |
Researcher | 24 | 8% |
Student > Doctoral Student | 18 | 6% |
Other | 42 | 14% |
Unknown | 111 | 36% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 69 | 23% |
Nursing and Health Professions | 48 | 16% |
Sports and Recreations | 21 | 7% |
Social Sciences | 9 | 3% |
Psychology | 6 | 2% |
Other | 30 | 10% |
Unknown | 122 | 40% |