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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Cytokine responses to Staphylococcus aureusbloodstream infection differ between patient cohorts that have different clinical courses of infection
|
|---|---|
| Published in |
BMC Infectious Diseases, November 2014
|
| DOI | 10.1186/s12879-014-0580-6 |
| Pubmed ID | |
| Authors |
Sinead McNicholas, Alida Fe Talento, Joanne O’Gorman, Margaret M Hannan, Maureen Lynch, Catherine M Greene, Hilary Humphreys, Deirdre Fitzgerald-Hughes |
| Abstract |
BackgroundThe clinical course of Staphylococcus aureus bloodstream infection is unpredictable and bacterial virulence, host immune response and patient characteristics are among the factors that contribute to the clinical course of infection. To investigate the relationship between cytokine response and clinical outcome, circulating cytokine levels were investigated in response to S. aureus bloodstream infection in patient with different clinical courses of infection.MethodsA prospective study was carried out in 61 patients with S. aureus bloodstream infection and circulating levels of IL-6, GRO-¿, RANTES and leptin were assessed over the course of the infection. Levels were compared in patients with complicated courses of infection (e.g. infective endocarditis) versus uncomplicated courses of S. aureus bloodstream infection and methicillin-resistant S. aureus Vs methicillin-susceptible S. aureus infection.ResultsSignificantly lower leptin levels (p¿<¿0.05) and significantly higher IL-6 levels (p¿<¿0.05) were detected at laboratory diagnosis in patients with complicated compared to uncomplicated S. aureus bloodstream infection. Significantly higher levels of GRO-¿ were associated with MRSA infection compared to MSSA infection.ConclusionsIL-6 may be an early inflammatory marker of complicated S. aureus bloodstream infection. Leptin may be protective against the development of a complicated S. aureus bloodstream infection. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 56 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 21% |
| Student > Master | 9 | 16% |
| Researcher | 8 | 14% |
| Student > Bachelor | 6 | 11% |
| Student > Doctoral Student | 4 | 7% |
| Other | 10 | 18% |
| Unknown | 7 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 15 | 27% |
| Biochemistry, Genetics and Molecular Biology | 8 | 14% |
| Agricultural and Biological Sciences | 8 | 14% |
| Immunology and Microbiology | 7 | 13% |
| Environmental Science | 1 | 2% |
| Other | 7 | 13% |
| Unknown | 10 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 November 2014.
All research outputs
#21,320,623
of 26,184,649 outputs
Outputs from BMC Infectious Diseases
#6,584
of 8,812 outputs
Outputs of similar age
#198,462
of 270,377 outputs
Outputs of similar age from BMC Infectious Diseases
#119
of 184 outputs
Altmetric has tracked 26,184,649 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,812 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.8. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,377 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 184 others from the same source and published within six weeks on either side of this one. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.