Title |
Cytokine responses to Staphylococcus aureusbloodstream infection differ between patient cohorts that have different clinical courses of infection
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Published in |
BMC Infectious Diseases, November 2014
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DOI | 10.1186/s12879-014-0580-6 |
Pubmed ID | |
Authors |
Sinead McNicholas, Alida Fe Talento, Joanne O’Gorman, Margaret M Hannan, Maureen Lynch, Catherine M Greene, Hilary Humphreys, Deirdre Fitzgerald-Hughes |
Abstract |
BackgroundThe clinical course of Staphylococcus aureus bloodstream infection is unpredictable and bacterial virulence, host immune response and patient characteristics are among the factors that contribute to the clinical course of infection. To investigate the relationship between cytokine response and clinical outcome, circulating cytokine levels were investigated in response to S. aureus bloodstream infection in patient with different clinical courses of infection.MethodsA prospective study was carried out in 61 patients with S. aureus bloodstream infection and circulating levels of IL-6, GRO-¿, RANTES and leptin were assessed over the course of the infection. Levels were compared in patients with complicated courses of infection (e.g. infective endocarditis) versus uncomplicated courses of S. aureus bloodstream infection and methicillin-resistant S. aureus Vs methicillin-susceptible S. aureus infection.ResultsSignificantly lower leptin levels (p¿<¿0.05) and significantly higher IL-6 levels (p¿<¿0.05) were detected at laboratory diagnosis in patients with complicated compared to uncomplicated S. aureus bloodstream infection. Significantly higher levels of GRO-¿ were associated with MRSA infection compared to MSSA infection.ConclusionsIL-6 may be an early inflammatory marker of complicated S. aureus bloodstream infection. Leptin may be protective against the development of a complicated S. aureus bloodstream infection. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 55 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 12 | 22% |
Student > Master | 9 | 16% |
Researcher | 8 | 15% |
Student > Bachelor | 6 | 11% |
Student > Doctoral Student | 4 | 7% |
Other | 9 | 16% |
Unknown | 7 | 13% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 15 | 27% |
Biochemistry, Genetics and Molecular Biology | 8 | 15% |
Agricultural and Biological Sciences | 8 | 15% |
Immunology and Microbiology | 7 | 13% |
Nursing and Health Professions | 1 | 2% |
Other | 6 | 11% |
Unknown | 10 | 18% |