Title |
Cannabinoid Receptor 2 Agonist Attenuates Pain Related Behavior in Rats with Chronic Alcohol/High Fat Diet Induced Pancreatitis
|
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Published in |
Molecular Pain, January 2014
|
DOI | 10.1186/1744-8069-10-66 |
Pubmed ID | |
Authors |
Liping Zhang, Robert H Kline, Terry A McNearney, Michael P Johnson, Karin N Westlund |
Abstract |
Chronic Pancreatitis (CP) is a complex and multifactorial syndrome. Many contributing factors result in development of dysfunctional pain in a significant number of patients. Drugs developed to treat a variety of pain states fall short of providing effective analgesia for patients with chronic pancreatitis, often providing minimal to partial pain relief over time with significant side effects. Recently, availability of selective pharmacological tools has enabled great advances in our knowledge of the role of the cannabinoid receptors in pathophysiology. In particular, cannabinoid receptor 2 (CB2) has emerged as an attractive target for management of chronic pain, as demonstrated in several studies with inflammatory and neuropathic preclinical pain models. In this study, the analgesic efficacy of a novel, highly selective CB2 receptor agonist, LY3038404 HCl, is investigated in a chronic pancreatitis pain model, induced with an alcohol/high fat (AHF) diet. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 29% |
United States | 1 | 14% |
Unknown | 4 | 57% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 7 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 2% |
United States | 1 | 2% |
Unknown | 58 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 13 | 22% |
Student > Master | 12 | 20% |
Researcher | 6 | 10% |
Unspecified | 5 | 8% |
Professor | 4 | 7% |
Other | 11 | 18% |
Unknown | 9 | 15% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 15 | 25% |
Psychology | 9 | 15% |
Agricultural and Biological Sciences | 6 | 10% |
Neuroscience | 5 | 8% |
Unspecified | 5 | 8% |
Other | 10 | 17% |
Unknown | 10 | 17% |