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Dynamics of double strand breaks and chromosomal translocations

Overview of attention for article published in Molecular Cancer, November 2014
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Title
Dynamics of double strand breaks and chromosomal translocations
Published in
Molecular Cancer, November 2014
DOI 10.1186/1476-4598-13-249
Pubmed ID
Authors

Olga V Iarovaia, Mikhail Rubtsov, Elena Ioudinkova, Tatiana Tsfasman, Sergey V Razin, Yegor S Vassetzky

Abstract

Chromosomal translocations are a major cause of cancer. At the same time, the mechanisms that lead to specific chromosomal translocations that associate different gene regions remain largely unknown. Translocations are induced by double strand breaks (DSBs) in DNA. Here we review recent data on the mechanisms of generation, mobility and repair of DSBs and stress the importance of the nuclear organization in this process.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 1%
Unknown 85 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 27 31%
Researcher 16 19%
Student > Master 12 14%
Student > Bachelor 9 10%
Student > Doctoral Student 4 5%
Other 9 10%
Unknown 9 10%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 39 45%
Agricultural and Biological Sciences 23 27%
Medicine and Dentistry 8 9%
Physics and Astronomy 2 2%
Nursing and Health Professions 1 1%
Other 1 1%
Unknown 12 14%