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Early administration of levosimendan is associated with improved kidney function after cardiac surgery – a retrospective analysis

Overview of attention for article published in Journal of Cardiothoracic Surgery, November 2014
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Title
Early administration of levosimendan is associated with improved kidney function after cardiac surgery – a retrospective analysis
Published in
Journal of Cardiothoracic Surgery, November 2014
DOI 10.1186/s13019-014-0167-8
Pubmed ID
Authors

Felix Balzer, Sascha Treskatsch, Claudia Spies, Michael Sander, Mark Kastrup, Herko Grubitzsch, Klaus-Dieter Wernecke, Jan P Braun

Abstract

BackgroundSeveral animal studies suggest beneficial effects on kidney function upon administration of levosimendan. As recent data from clinical studies are heterogeneous, we sought to investigate whether levosimendan is associated with improved postoperative kidney function in cardiac surgery patients with respect to timing of its administration.MethodsRetrospective, single centre, observational analysis at a university hospital in Berlin, Germany. All adult patients without preoperative renal dysfunction that underwent coronary artery bypass grafting and/or valve reconstruction/replacement between 01/01/2007 and 31/12/2011 were considered for analyses.ResultsOut of 1.095 included patients, 46 patients were treated with levosimendan due to a severely reduced left ventricular systolic function preoperatively (LVEF¿<¿35%) and/or clinical signs of a low cardiac output syndrome. Sixty-one percent received the drug whilst in the OR, 39% after postoperative intensive care unit admission. When levosimendan was given immediately after anaesthesia induction, creatinine plasma levels (p¿=¿0.009 for nonparametric analysis of longitudinal data in a two-factorial design) and incidence of postoperative renal dysfunction (67.9% vs. 94.4%; p¿=¿0.033) were significantly reduced in contrast to a later start of treatment. In addition, duration of renal replacement therapy was significantly shorter (79 [35;332] vs. 272 [132;703] minutes; p¿=¿0.046) in that group.ConclusionsPostoperative kidney dysfunction is a common condition in patients under going cardiac surgery. Patients with severely reduced left ventricular function and/or clinical signs of a low cardiac output syndrome who preoperatively presented with a normal kidney function may benefit from an early start of levosimendan administration, i.e. immediately after anaesthesia.Trial registrationClinicaltrials.gov-ID: NCT01918618.

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Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 24 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 17%
Student > Bachelor 3 13%
Other 3 13%
Student > Ph. D. Student 3 13%
Lecturer 2 8%
Other 3 13%
Unknown 6 25%
Readers by discipline Count As %
Medicine and Dentistry 14 58%
Nursing and Health Professions 2 8%
Veterinary Science and Veterinary Medicine 1 4%
Computer Science 1 4%
Agricultural and Biological Sciences 1 4%
Other 0 0%
Unknown 5 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 December 2016.
All research outputs
#11,062,084
of 12,443,702 outputs
Outputs from Journal of Cardiothoracic Surgery
#354
of 437 outputs
Outputs of similar age
#227,563
of 280,043 outputs
Outputs of similar age from Journal of Cardiothoracic Surgery
#25
of 31 outputs
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So far Altmetric has tracked 437 research outputs from this source. They receive a mean Attention Score of 2.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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