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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Histaminergic system in brain disorders: lessons from the translational approach and future perspectives
|
|---|---|
| Published in |
Annals of General Psychiatry, November 2014
|
| DOI | 10.1186/s12991-014-0034-y |
| Pubmed ID | |
| Authors |
Diego Baronio, Taylor Gonchoroski, Kamila Castro, Geancarlo Zanatta, Carmem Gottfried, Rudimar Riesgo |
| Abstract |
Histamine and its receptors were first described as part of immune and gastrointestinal systems, but their presence in the central nervous system and importance in behavior are gaining more attention. The histaminergic system modulates different processes including wakefulness, feeding, and learning and memory consolidation. Histamine receptors (H1R, H2R, H3R, and H4R) belong to the rhodopsin-like family of G protein-coupled receptors, present constitutive activity, and are subjected to inverse agonist action. The involvement of the histaminergic system in brain disorders, such as Alzheimer's disease, schizophrenia, sleep disorders, drug dependence, and Parkinson's disease, is largely studied. Data obtained from preclinical studies point antagonists of histamine receptors as promising alternatives to treat brain disorders. Thus, clinical trials are currently ongoing to assess the effects of these drugs on humans. This review summarizes the role of histaminergic system in brain disorders, as well as the effects of different histamine antagonists on animal models and humans. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 40% |
| United States | 1 | 20% |
| Unknown | 2 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 126 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | <1% |
| Canada | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 123 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 18 | 14% |
| Student > Master | 18 | 14% |
| Student > Bachelor | 13 | 10% |
| Student > Ph. D. Student | 8 | 6% |
| Student > Doctoral Student | 7 | 6% |
| Other | 29 | 23% |
| Unknown | 33 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 20 | 16% |
| Psychology | 14 | 11% |
| Neuroscience | 13 | 10% |
| Agricultural and Biological Sciences | 10 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 5% |
| Other | 23 | 18% |
| Unknown | 40 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 July 2015.
All research outputs
#2,876,056
of 25,654,806 outputs
Outputs from Annals of General Psychiatry
#88
of 567 outputs
Outputs of similar age
#38,545
of 371,415 outputs
Outputs of similar age from Annals of General Psychiatry
#1
of 10 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 567 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.0. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 371,415 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them