Title |
FOXP1inhibits cell growth and attenuates tumorigenicity of neuroblastoma
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Published in |
BMC Cancer, November 2014
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DOI | 10.1186/1471-2407-14-840 |
Pubmed ID | |
Authors |
Sandra Ackermann, Hayriye Kocak, Barbara Hero, Volker Ehemann, Yvonne Kahlert, André Oberthuer, Frederik Roels, Jessica Theißen, Margarete Odenthal, Frank Berthold, Matthias Fischer |
Abstract |
Segmental genomic copy number alterations, such as loss of 11q or 3p and gain of 17q, are well established markers of poor outcome in neuroblastoma, and have been suggested to comprise tumor suppressor genes or oncogenes, respectively. The gene forkhead box P1 (FOXP1) maps to chromosome 3p14.1, a tumor suppressor locus deleted in many human cancers including neuroblastoma. FoxP1 belongs to a family of winged-helix transcription factors that are involved in processes of cellular proliferation, differentiation and neoplastic transformation. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 3% |
Belgium | 1 | 3% |
Unknown | 38 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 8 | 20% |
Researcher | 6 | 15% |
Student > Doctoral Student | 4 | 10% |
Student > Master | 4 | 10% |
Student > Bachelor | 3 | 8% |
Other | 3 | 8% |
Unknown | 12 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 10 | 25% |
Medicine and Dentistry | 6 | 15% |
Biochemistry, Genetics and Molecular Biology | 5 | 13% |
Psychology | 2 | 5% |
Business, Management and Accounting | 1 | 3% |
Other | 2 | 5% |
Unknown | 14 | 35% |