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HALT-IT - tranexamic acid for the treatment of gastrointestinal bleeding: study protocol for a randomised controlled trial

Overview of attention for article published in Trials, November 2014
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Title
HALT-IT - tranexamic acid for the treatment of gastrointestinal bleeding: study protocol for a randomised controlled trial
Published in
Trials, November 2014
DOI 10.1186/1745-6215-15-450
Pubmed ID
Authors

Ian Roberts, Timothy Coats, Phil Edwards, Ian Gilmore, Vipul Jairath, Katharine Ker, Daniela Manno, Haleema Shakur, Simon Stanworth, Andrew Veitch

Abstract

Gastrointestinal bleeding is a common emergency that causes substantial mortality worldwide. Acute upper and lower gastrointestinal bleeding accounts for about 75,000 hospital admissions each year in the UK and causes the death of about 10% of these patients. Tranexamic acid has been shown to reduce the need for blood transfusion in surgical patients and to reduce mortality in bleeding trauma patients, with no apparent increase in thromboembolic events. A systematic review of clinical trials of upper gastrointestinal bleeding shows a reduction in the risk of death with tranexamic acid but the quality of the trials was poor and the estimates are imprecise. The trials were also too small to assess the effect of tranexamic acid on thromboembolic events.

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X Demographics

The data shown below were collected from the profiles of 15 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 164 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Unknown 163 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 20 12%
Student > Bachelor 20 12%
Student > Master 17 10%
Student > Postgraduate 16 10%
Other 13 8%
Other 37 23%
Unknown 41 25%
Readers by discipline Count As %
Medicine and Dentistry 86 52%
Pharmacology, Toxicology and Pharmaceutical Science 10 6%
Agricultural and Biological Sciences 7 4%
Economics, Econometrics and Finance 2 1%
Psychology 2 1%
Other 11 7%
Unknown 46 28%