Title |
HALT-IT - tranexamic acid for the treatment of gastrointestinal bleeding: study protocol for a randomised controlled trial
|
---|---|
Published in |
Trials, November 2014
|
DOI | 10.1186/1745-6215-15-450 |
Pubmed ID | |
Authors |
Ian Roberts, Timothy Coats, Phil Edwards, Ian Gilmore, Vipul Jairath, Katharine Ker, Daniela Manno, Haleema Shakur, Simon Stanworth, Andrew Veitch |
Abstract |
Gastrointestinal bleeding is a common emergency that causes substantial mortality worldwide. Acute upper and lower gastrointestinal bleeding accounts for about 75,000 hospital admissions each year in the UK and causes the death of about 10% of these patients. Tranexamic acid has been shown to reduce the need for blood transfusion in surgical patients and to reduce mortality in bleeding trauma patients, with no apparent increase in thromboembolic events. A systematic review of clinical trials of upper gastrointestinal bleeding shows a reduction in the risk of death with tranexamic acid but the quality of the trials was poor and the estimates are imprecise. The trials were also too small to assess the effect of tranexamic acid on thromboembolic events. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 5 | 33% |
United Kingdom | 3 | 20% |
Canada | 1 | 7% |
Japan | 1 | 7% |
Unknown | 5 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 9 | 60% |
Practitioners (doctors, other healthcare professionals) | 3 | 20% |
Scientists | 3 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | <1% |
Unknown | 163 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 20 | 12% |
Student > Bachelor | 20 | 12% |
Student > Master | 17 | 10% |
Student > Postgraduate | 16 | 10% |
Other | 13 | 8% |
Other | 37 | 23% |
Unknown | 41 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 86 | 52% |
Pharmacology, Toxicology and Pharmaceutical Science | 10 | 6% |
Agricultural and Biological Sciences | 7 | 4% |
Economics, Econometrics and Finance | 2 | 1% |
Psychology | 2 | 1% |
Other | 11 | 7% |
Unknown | 46 | 28% |