↓ Skip to main content

Differential biologic effects of CPD and 6-4PP UV-induced DNA damage on the induction of apoptosis and cell-cycle arrest

Overview of attention for article published in BMC Cancer, October 2005
Altmetric Badge

Mentioned by

twitter
1 X user

Citations

dimensions_citation
116 Dimensions

Readers on

mendeley
158 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Differential biologic effects of CPD and 6-4PP UV-induced DNA damage on the induction of apoptosis and cell-cycle arrest
Published in
BMC Cancer, October 2005
DOI 10.1186/1471-2407-5-135
Pubmed ID
Authors

Hsin-Lung Lo, Satoshi Nakajima, Lisa Ma, Barbara Walter, Akira Yasui, Douglas W Ethell, Laurie B Owen

Abstract

UV-induced damage can induce apoptosis or trigger DNA repair mechanisms. Minor DNA damage is thought to halt the cell cycle to allow effective repair, while more severe damage can induce an apoptotic program. Of the two major types of UV-induced DNA lesions, it has been reported that repair of CPD, but not 6-4PP, abrogates mutation. To address whether the two major forms of UV-induced DNA damage, can induce differential biological effects, NER-deficient cells containing either CPD photolyase or 6-4 PP photolyase were exposed to UV and examined for alterations in cell cycle and apoptosis. In addition, pTpT, a molecular mimic of CPD was tested in vitro and in vivo for the ability to induce cell death and cell cycle alterations.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 158 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 1%
India 2 1%
United Kingdom 1 <1%
Unknown 153 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 37 23%
Student > Master 24 15%
Student > Bachelor 22 14%
Researcher 21 13%
Student > Doctoral Student 7 4%
Other 16 10%
Unknown 31 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 49 31%
Biochemistry, Genetics and Molecular Biology 37 23%
Medicine and Dentistry 12 8%
Chemistry 11 7%
Pharmacology, Toxicology and Pharmaceutical Science 3 2%
Other 12 8%
Unknown 34 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 November 2014.
All research outputs
#18,384,336
of 22,771,140 outputs
Outputs from BMC Cancer
#5,416
of 8,281 outputs
Outputs of similar age
#55,433
of 58,977 outputs
Outputs of similar age from BMC Cancer
#8
of 9 outputs
Altmetric has tracked 22,771,140 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,281 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 58,977 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 3rd percentile – i.e., 3% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one.