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X Demographics
Mendeley readers
Attention Score in Context
| Title |
N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor
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|---|---|
| Published in |
BMC Neuroscience, March 2010
|
| DOI | 10.1186/1471-2202-11-44 |
| Pubmed ID | |
| Authors |
Douglas McHugh, Sherry SJ Hu, Neta Rimmerman, Ana Juknat, Zvi Vogel, J Michael Walker, Heather B Bradshaw |
| Abstract |
Microglia provide continuous immune surveillance of the CNS and upon activation rapidly change phenotype to express receptors that respond to chemoattractants during CNS damage or infection. These activated microglia undergo directed migration towards affected tissue. Importantly, the molecular species of chemoattractant encountered determines if microglia respond with pro- or anti-inflammatory behaviour, yet the signaling molecules that trigger migration remain poorly understood. The endogenous cannabinoid system regulates microglial migration via CB2 receptors and an as yet unidentified GPCR termed the 'abnormal cannabidiol' (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of the phytocannabinoid cannabidiol (CBD) and is inactive at CB1 or CB2 receptors, but functions as a selective agonist at this Gi/o-coupled GPCR. N-arachidonoyl glycine (NAGly) is an endogenous metabolite of the endocannabinoid anandamide and acts as an efficacious agonist at GPR18. Here, we investigate the relationship between NAGly, Abn-CBD, the unidentified 'Abn-CBD' receptor, GPR18, and BV-2 microglial migration. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 221 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 3 | 1% |
| United Kingdom | 3 | 1% |
| United States | 2 | <1% |
| Spain | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 211 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 41 | 19% |
| Student > Ph. D. Student | 40 | 18% |
| Student > Bachelor | 34 | 15% |
| Student > Master | 29 | 13% |
| Other | 13 | 6% |
| Other | 27 | 12% |
| Unknown | 37 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 50 | 23% |
| Biochemistry, Genetics and Molecular Biology | 35 | 16% |
| Medicine and Dentistry | 25 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 21 | 10% |
| Chemistry | 13 | 6% |
| Other | 38 | 17% |
| Unknown | 39 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 June 2023.
All research outputs
#4,340,769
of 23,989,432 outputs
Outputs from BMC Neuroscience
#193
of 1,267 outputs
Outputs of similar age
#18,173
of 97,581 outputs
Outputs of similar age from BMC Neuroscience
#3
of 18 outputs
Altmetric has tracked 23,989,432 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,267 research outputs from this source. They receive a mean Attention Score of 4.5. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 97,581 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.