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N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor

Overview of attention for article published in BMC Neuroscience, March 2010
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (81st percentile)
  • High Attention Score compared to outputs of the same age and source (88th percentile)

Mentioned by

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2 X users
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1 patent
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13 Wikipedia pages

Citations

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252 Dimensions

Readers on

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223 Mendeley
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2 CiteULike
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Title
N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor
Published in
BMC Neuroscience, March 2010
DOI 10.1186/1471-2202-11-44
Pubmed ID
Authors

Douglas McHugh, Sherry SJ Hu, Neta Rimmerman, Ana Juknat, Zvi Vogel, J Michael Walker, Heather B Bradshaw

Abstract

Microglia provide continuous immune surveillance of the CNS and upon activation rapidly change phenotype to express receptors that respond to chemoattractants during CNS damage or infection. These activated microglia undergo directed migration towards affected tissue. Importantly, the molecular species of chemoattractant encountered determines if microglia respond with pro- or anti-inflammatory behaviour, yet the signaling molecules that trigger migration remain poorly understood. The endogenous cannabinoid system regulates microglial migration via CB2 receptors and an as yet unidentified GPCR termed the 'abnormal cannabidiol' (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of the phytocannabinoid cannabidiol (CBD) and is inactive at CB1 or CB2 receptors, but functions as a selective agonist at this Gi/o-coupled GPCR. N-arachidonoyl glycine (NAGly) is an endogenous metabolite of the endocannabinoid anandamide and acts as an efficacious agonist at GPR18. Here, we investigate the relationship between NAGly, Abn-CBD, the unidentified 'Abn-CBD' receptor, GPR18, and BV-2 microglial migration.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 223 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 3 1%
United Kingdom 3 1%
United States 2 <1%
Spain 1 <1%
Germany 1 <1%
Unknown 213 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 41 18%
Researcher 39 17%
Student > Bachelor 34 15%
Student > Master 29 13%
Other 13 6%
Other 27 12%
Unknown 40 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 50 22%
Biochemistry, Genetics and Molecular Biology 35 16%
Medicine and Dentistry 25 11%
Pharmacology, Toxicology and Pharmaceutical Science 21 9%
Chemistry 13 6%
Other 36 16%
Unknown 43 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 June 2023.
All research outputs
#4,340,769
of 23,989,432 outputs
Outputs from BMC Neuroscience
#193
of 1,267 outputs
Outputs of similar age
#18,173
of 97,581 outputs
Outputs of similar age from BMC Neuroscience
#3
of 18 outputs
Altmetric has tracked 23,989,432 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,267 research outputs from this source. They receive a mean Attention Score of 4.5. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 97,581 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.