Title |
N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor
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Published in |
BMC Neuroscience, March 2010
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DOI | 10.1186/1471-2202-11-44 |
Pubmed ID | |
Authors |
Douglas McHugh, Sherry SJ Hu, Neta Rimmerman, Ana Juknat, Zvi Vogel, J Michael Walker, Heather B Bradshaw |
Abstract |
Microglia provide continuous immune surveillance of the CNS and upon activation rapidly change phenotype to express receptors that respond to chemoattractants during CNS damage or infection. These activated microglia undergo directed migration towards affected tissue. Importantly, the molecular species of chemoattractant encountered determines if microglia respond with pro- or anti-inflammatory behaviour, yet the signaling molecules that trigger migration remain poorly understood. The endogenous cannabinoid system regulates microglial migration via CB2 receptors and an as yet unidentified GPCR termed the 'abnormal cannabidiol' (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of the phytocannabinoid cannabidiol (CBD) and is inactive at CB1 or CB2 receptors, but functions as a selective agonist at this Gi/o-coupled GPCR. N-arachidonoyl glycine (NAGly) is an endogenous metabolite of the endocannabinoid anandamide and acts as an efficacious agonist at GPR18. Here, we investigate the relationship between NAGly, Abn-CBD, the unidentified 'Abn-CBD' receptor, GPR18, and BV-2 microglial migration. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Canada | 3 | 1% |
United Kingdom | 3 | 1% |
United States | 2 | <1% |
Spain | 1 | <1% |
Germany | 1 | <1% |
Unknown | 211 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 41 | 19% |
Student > Ph. D. Student | 40 | 18% |
Student > Bachelor | 34 | 15% |
Student > Master | 29 | 13% |
Other | 13 | 6% |
Other | 27 | 12% |
Unknown | 37 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 50 | 23% |
Biochemistry, Genetics and Molecular Biology | 35 | 16% |
Medicine and Dentistry | 25 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 21 | 10% |
Chemistry | 13 | 6% |
Other | 38 | 17% |
Unknown | 39 | 18% |