Title |
Functional chromatin features are associated with structural mutations in cancer
|
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Published in |
BMC Genomics, November 2014
|
DOI | 10.1186/1471-2164-15-1013 |
Pubmed ID | |
Authors |
Krzysztof R Grzeda, Beryl Royer-Bertrand, Koichiro Inaki, Hyunsoo Kim, Axel M Hillmer, Edison T Liu, Jeffrey H Chuang |
Abstract |
Structural mutations (SMs) play a major role in cancer development. In some cancers, such as breast and ovarian, DNA double-strand breaks (DSBs) occur more frequently in transcribed regions, while in other cancer types such as prostate, there is a consistent depletion of breakpoints in transcribed regions. Despite such regularity, little is understood about the mechanisms driving these effects. A few works have suggested that protein binding may be relevant, e.g. in studies of androgen receptor binding and active chromatin in specific cell types. We hypothesized that this behavior might be general, i.e. that correlation between protein-DNA binding (and open chromatin) and breakpoint locations is common across divergent cancers. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 14% |
India | 1 | 14% |
France | 1 | 14% |
Unknown | 4 | 57% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 5 | 71% |
Scientists | 1 | 14% |
Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Mexico | 1 | 4% |
Unknown | 22 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 5 | 22% |
Researcher | 5 | 22% |
Student > Ph. D. Student | 5 | 22% |
Other | 2 | 9% |
Student > Doctoral Student | 1 | 4% |
Other | 3 | 13% |
Unknown | 2 | 9% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 8 | 35% |
Biochemistry, Genetics and Molecular Biology | 6 | 26% |
Medicine and Dentistry | 4 | 17% |
Arts and Humanities | 1 | 4% |
Immunology and Microbiology | 1 | 4% |
Other | 1 | 4% |
Unknown | 2 | 9% |