Title |
The impact of mitochondrial function/dysfunction on IVF and new treatment possibilities for infertility
|
---|---|
Published in |
Reproductive Biology and Endocrinology, November 2014
|
DOI | 10.1186/1477-7827-12-111 |
Pubmed ID | |
Authors |
Heide Schatten, Qing-Yuan Sun, Randall Prather |
Abstract |
Mitochondria play vital roles in oocyte functions and they are critical indicators of oocyte quality which is important for fertilization and development into viable offspring. Quality-compromised oocytes are correlated with infertility, developmental disorders, reduced blastocyst cell number and embryo loss in which mitochondrial dysfunctions play a significant role. Increasingly, women affected by metabolic disorders such as diabetes or obesity and oocyte aging are seeking treatment in IVF clinics to overcome the effects of adverse metabolic conditions on mitochondrial functions and new treatments have become available to restore oocyte quality. The past decade has seen enormous advances in potential therapies to restore oocyte quality and includes dietary components and transfer of mitochondria from cells with mitochondrial integrity into mitochondria-impaired oocytes. New technologies have opened up new possibilities for therapeutic advances which will increase the success rates for IVF of oocytes from women with compromised oocyte quality. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 50% |
Canada | 1 | 25% |
Japan | 1 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 1% |
Unknown | 147 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 25 | 17% |
Student > Ph. D. Student | 23 | 15% |
Student > Bachelor | 21 | 14% |
Researcher | 18 | 12% |
Student > Doctoral Student | 10 | 7% |
Other | 27 | 18% |
Unknown | 25 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 35 | 23% |
Agricultural and Biological Sciences | 35 | 23% |
Medicine and Dentistry | 31 | 21% |
Computer Science | 5 | 3% |
Chemistry | 4 | 3% |
Other | 9 | 6% |
Unknown | 30 | 20% |