Title |
Dissecting the organ specificity of insecticide resistance candidate genes in Anopheles gambiae: known and novel candidate genes
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Published in |
BMC Genomics, November 2014
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DOI | 10.1186/1471-2164-15-1018 |
Pubmed ID | |
Authors |
Victoria A Ingham, Christopher M Jones, Patricia Pignatelli, Vasileia Balabanidou, John Vontas, Simon C Wagstaff, Jonathan D Moore, Hilary Ranson |
Abstract |
The elevated expression of enzymes with insecticide metabolism activity can lead to high levels of insecticide resistance in the malaria vector, Anopheles gambiae. In this study, adult female mosquitoes from an insecticide susceptible and resistant strain were dissected into four different body parts. RNA from each of these samples was used in microarray analysis to determine the enrichment patterns of the key detoxification gene families within the mosquito and to identify additional candidate insecticide resistance genes that may have been overlooked in previous experiments on whole organisms. |
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Mendeley readers
Geographical breakdown
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Student > Postgraduate | 5 | 5% |
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