Title |
Molecular evidence for increased regulatory conservation during metamorphosis, and against deleterious cascading effects of hybrid breakdown in Drosophila
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Published in |
BMC Biology, March 2010
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DOI | 10.1186/1741-7007-8-26 |
Pubmed ID | |
Authors |
Carlo G Artieri, Rama S Singh |
Abstract |
Speculation regarding the importance of changes in gene regulation in determining major phylogenetic patterns continues to accrue, despite a lack of broad-scale comparative studies examining how patterns of gene expression vary during development. Comparative transcriptional profiling of adult interspecific hybrids and their parental species has uncovered widespread divergence of the mechanisms controlling gene regulation, revealing incompatibilities that are masked in comparisons between the pure species. However, this has prompted the suggestion that misexpression in adult hybrids results from the downstream cascading effects of a subset of genes improperly regulated in early development. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 8% |
United Kingdom | 1 | 4% |
Spain | 1 | 4% |
Sweden | 1 | 4% |
Unknown | 21 | 81% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 9 | 35% |
Researcher | 4 | 15% |
Student > Master | 3 | 12% |
Professor | 2 | 8% |
Other | 2 | 8% |
Other | 2 | 8% |
Unknown | 4 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 15 | 58% |
Biochemistry, Genetics and Molecular Biology | 4 | 15% |
Computer Science | 2 | 8% |
Medicine and Dentistry | 1 | 4% |
Unknown | 4 | 15% |