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Mendeley readers
Attention Score in Context
| Title |
Dynamic gene expressions of peripheral blood mononuclear cells in patients with acute exacerbation of chronic obstructive pulmonary disease: a preliminary study
|
|---|---|
| Published in |
Critical Care, November 2014
|
| DOI | 10.1186/s13054-014-0508-y |
| Pubmed ID | |
| Authors |
Xiaodan Wu, Xiaoru Sun, Chengshui Chen, Chunxue Bai, Xiangdong Wang |
| Abstract |
IntroductionAcute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a serious event, responsible for the progress of the disease, increases in medical costs, and high mortality.MethodsThe present study aimed to identify AECOPD-specific biomarkers by evaluating the dynamic gene profiling of peripheral blood mononuclear cells (PBMCs) from patients with AECOPD on days 1, 3 and 10 after hospital admission, to compare with healthy controls or patients with stable COPD.ResultsWe found that 14 genes were co-differentially upregulated and 2 downregulated over 10-fold in patients with COPD or AECOPD, compared with the healthy individuals. Eight co-differentially upregulated genes and six downregulated genes were identified as a panel of AECOPD-specific genes. Downregulation of TCF7 in PBMCs was found to be associated with the severity of COPD. Dynamic changes of Aminolevulinate-delta-synthase 2 and carbonic anhydrase I had similar patterns of Digital Evaluation Score System and may serve as potential genes during the course of AECOPD.ConclusionThus, our findings indicate a panel of altered gene expression patterns in PBMCs can be used as AECOPD-specific dynamic biomarkers to monitor the course of the disease. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 2% |
| Brazil | 1 | 2% |
| Unknown | 41 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 10 | 23% |
| Student > Master | 7 | 16% |
| Student > Ph. D. Student | 5 | 12% |
| Student > Bachelor | 4 | 9% |
| Other | 2 | 5% |
| Other | 4 | 9% |
| Unknown | 11 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 7 | 16% |
| Agricultural and Biological Sciences | 7 | 16% |
| Biochemistry, Genetics and Molecular Biology | 5 | 12% |
| Immunology and Microbiology | 4 | 9% |
| Nursing and Health Professions | 1 | 2% |
| Other | 4 | 9% |
| Unknown | 15 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 November 2014.
All research outputs
#20,656,161
of 25,373,627 outputs
Outputs from Critical Care
#5,970
of 6,554 outputs
Outputs of similar age
#274,698
of 369,967 outputs
Outputs of similar age from Critical Care
#147
of 167 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,554 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.8. This one is in the 2nd percentile – i.e., 2% of its peers scored the same or lower than it.
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We're also able to compare this research output to 167 others from the same source and published within six weeks on either side of this one. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.