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Recurrent genetic alterations in hepatitis C-associated hepatocellular carcinoma detected by genomic microarray: a genetic, clinical and pathological correlation study

Overview of attention for article published in Molecular Cytogenetics, November 2014
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Title
Recurrent genetic alterations in hepatitis C-associated hepatocellular carcinoma detected by genomic microarray: a genetic, clinical and pathological correlation study
Published in
Molecular Cytogenetics, November 2014
DOI 10.1186/s13039-014-0081-8
Pubmed ID
Authors

Yajuan J Liu, Yang Zhou, Matthew M Yeh

Abstract

In the US, approximately 50% of hepatocellular carcinoma (HCC) is caused by hepatitis-C virus (HCV) infection. The molecular mechanism of a malignant transformation of hepatocyte induced by HCV infection is still largely unclear. There are several clinical and pathological staging systems for HCC, but none of them include biological parameters as predictors for prognosis and there has not been a standardized molecular classification of HCC. To understand the underlying pathogenic genetic alterations in HCV-associated HCC and aid in molecular classification of HCC and patient prognosis, microarray analysis of DNA copy number alterations in HCC were conducted using whole genome microarray with DNA from formalin-fixed paraffin-embedded (FFPE) specimens of both cancer tissues and paired nearby cirrhotic non-neoplastic tissues.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 20%
Student > Ph. D. Student 4 20%
Student > Doctoral Student 2 10%
Student > Bachelor 2 10%
Other 2 10%
Other 4 20%
Unknown 2 10%
Readers by discipline Count As %
Medicine and Dentistry 5 25%
Biochemistry, Genetics and Molecular Biology 3 15%
Agricultural and Biological Sciences 2 10%
Immunology and Microbiology 1 5%
Computer Science 1 5%
Other 2 10%
Unknown 6 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 December 2014.
All research outputs
#20,243,777
of 22,771,140 outputs
Outputs from Molecular Cytogenetics
#297
of 400 outputs
Outputs of similar age
#302,833
of 361,642 outputs
Outputs of similar age from Molecular Cytogenetics
#19
of 25 outputs
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So far Altmetric has tracked 400 research outputs from this source. They receive a mean Attention Score of 2.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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