Title |
Recurrent genetic alterations in hepatitis C-associated hepatocellular carcinoma detected by genomic microarray: a genetic, clinical and pathological correlation study
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Published in |
Molecular Cytogenetics, November 2014
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DOI | 10.1186/s13039-014-0081-8 |
Pubmed ID | |
Authors |
Yajuan J Liu, Yang Zhou, Matthew M Yeh |
Abstract |
In the US, approximately 50% of hepatocellular carcinoma (HCC) is caused by hepatitis-C virus (HCV) infection. The molecular mechanism of a malignant transformation of hepatocyte induced by HCV infection is still largely unclear. There are several clinical and pathological staging systems for HCC, but none of them include biological parameters as predictors for prognosis and there has not been a standardized molecular classification of HCC. To understand the underlying pathogenic genetic alterations in HCV-associated HCC and aid in molecular classification of HCC and patient prognosis, microarray analysis of DNA copy number alterations in HCC were conducted using whole genome microarray with DNA from formalin-fixed paraffin-embedded (FFPE) specimens of both cancer tissues and paired nearby cirrhotic non-neoplastic tissues. |
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Unknown | 1 | 100% |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 20 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 4 | 20% |
Student > Ph. D. Student | 4 | 20% |
Student > Doctoral Student | 2 | 10% |
Student > Bachelor | 2 | 10% |
Other | 2 | 10% |
Other | 4 | 20% |
Unknown | 2 | 10% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 5 | 25% |
Biochemistry, Genetics and Molecular Biology | 3 | 15% |
Agricultural and Biological Sciences | 2 | 10% |
Immunology and Microbiology | 1 | 5% |
Computer Science | 1 | 5% |
Other | 2 | 10% |
Unknown | 6 | 30% |