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Drug resistance genomics of the antimalarial drug artemisinin

Overview of attention for article published in Genome Biology (Online Edition), November 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (92nd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (56th percentile)

Mentioned by

blogs
1 blog
twitter
5 tweeters
facebook
3 Facebook pages
wikipedia
2 Wikipedia pages
googleplus
2 Google+ users

Citations

dimensions_citation
61 Dimensions

Readers on

mendeley
272 Mendeley
citeulike
1 CiteULike
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Title
Drug resistance genomics of the antimalarial drug artemisinin
Published in
Genome Biology (Online Edition), November 2014
DOI 10.1186/s13059-014-0544-6
Pubmed ID
Authors

Elizabeth A Winzeler, Micah J Manary

Abstract

Across the globe, over 200 million annual malaria infections result in up to 660,000 deaths, 77% of which occur in children under the age of five years. Although prevention is important, malaria deaths are typically prevented by using antimalarial drugs that eliminate symptoms and clear parasites from the blood. Artemisinins are one of the few remaining compound classes that can be used to cure multidrug-resistant Plasmodium falciparum infections. Unfortunately, clinical trials from Southeast Asia are showing that artemisinin-based treatments are beginning to lose their effectiveness, adding renewed urgency to the search for the genetic determinants of parasite resistance to this important drug class. We review the genetic and genomic approaches that have led to an improved understanding of artemisinin resistance, including the identification of resistance-conferring mutations in the P. falciparum kelch13 gene.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 272 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 <1%
United States 2 <1%
Vietnam 1 <1%
Ghana 1 <1%
Brazil 1 <1%
Burkina Faso 1 <1%
Taiwan 1 <1%
Senegal 1 <1%
Unknown 262 96%

Demographic breakdown

Readers by professional status Count As %
Student > Master 58 21%
Student > Ph. D. Student 46 17%
Researcher 43 16%
Student > Bachelor 28 10%
Student > Postgraduate 17 6%
Other 51 19%
Unknown 29 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 72 26%
Biochemistry, Genetics and Molecular Biology 64 24%
Medicine and Dentistry 27 10%
Chemistry 24 9%
Pharmacology, Toxicology and Pharmaceutical Science 16 6%
Other 30 11%
Unknown 39 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 February 2016.
All research outputs
#1,234,665
of 17,353,889 outputs
Outputs from Genome Biology (Online Edition)
#1,223
of 3,593 outputs
Outputs of similar age
#23,044
of 314,322 outputs
Outputs of similar age from Genome Biology (Online Edition)
#37
of 86 outputs
Altmetric has tracked 17,353,889 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,593 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 26.6. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 314,322 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 86 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.