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Serum 25(OH)D concentrations and atopic diseases at age 10: results from the GINIplus and LISAplus birth cohort studies

Overview of attention for article published in BMC Pediatrics, November 2014
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Title
Serum 25(OH)D concentrations and atopic diseases at age 10: results from the GINIplus and LISAplus birth cohort studies
Published in
BMC Pediatrics, November 2014
DOI 10.1186/s12887-014-0286-3
Pubmed ID
Authors

Nina Wawro, Joachim Heinrich, Elisabeth Thiering, Jürgen Kratzsch, Beate Schaaf, Barbara Hoffmann, Irina Lehmann, Carl-Peter Bauer, Sibylle Koletzko, Andrea von Berg, Dietrich Berdel, Jakob Linseisen

Abstract

BackgroundVitamin D is well recognized for its role in skeletal health and its involvement in the modulation of the immune system. In the literature, controversial results are reported for atopic diseases. Thus, we investigated the association between vitamin D status and the prevalence of atopic diseases.MethodsSerum 25-hydroxy-vitamin D (25(OH)D) concentrations were measured in a sample of 2815 10-years old children from two German birth cohort studies. Self-reported physician-diagnosed eczema, hay fever or allergic rhinitis, and asthma were used as outcome variables as well as specific IgE positivity against common allergens. We applied logistic regression models, deriving adjusted odds ratio estimates (aOR) and 95% confidence intervals (CI).ResultsFor asthma and hay fever or allergic rhinitis, no associations existed with serum 25(OH)D concentrations. We observed a significant positive relationship between serum 25(OH)D levels and eczema at age 10 (aOR¿=¿1.09, CI¿=¿1.01-1.17, per 10 nmol/l increase in serum 25(OH)D levels) and for the lifetime prevalence of eczema (aOR¿=¿1.05, CI¿=¿1.01-1.09). Specific IgE positivity for food allergens (aOR¿=¿1.07, CI¿=¿1.02-1.11) and aeroallergens (aOR¿=¿1.05, CI¿=¿1.01-1.08) at age 10, as well as lifetime prevalence, was significantly related to the vitamin D status.ConclusionIn this study we found no indication that higher blood 25(OH)D levels are associated with decreased risk for any of the atopic outcomes in children. However, we observed a positive association of serum 25(OH)D concentrations with eczema and detectable specific IgE. Due to the given limitations of our study, the clinical relevance of these findings needs further clarification.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 55 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 12 22%
Student > Bachelor 8 15%
Student > Ph. D. Student 6 11%
Student > Doctoral Student 4 7%
Student > Postgraduate 4 7%
Other 9 16%
Unknown 12 22%
Readers by discipline Count As %
Medicine and Dentistry 26 47%
Nursing and Health Professions 4 7%
Agricultural and Biological Sciences 3 5%
Environmental Science 2 4%
Biochemistry, Genetics and Molecular Biology 1 2%
Other 4 7%
Unknown 15 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 July 2015.
All research outputs
#16,919,456
of 25,654,806 outputs
Outputs from BMC Pediatrics
#2,137
of 3,494 outputs
Outputs of similar age
#218,697
of 371,084 outputs
Outputs of similar age from BMC Pediatrics
#21
of 37 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,494 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one is in the 34th percentile – i.e., 34% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 371,084 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 37 others from the same source and published within six weeks on either side of this one. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.