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Improved insulin sensitivity and body composition, irrespective of macronutrient intake, after a 12 month intervention in adolescents with pre-diabetes; RESIST a randomised control trial

Overview of attention for article published in BMC Pediatrics, November 2014
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Title
Improved insulin sensitivity and body composition, irrespective of macronutrient intake, after a 12 month intervention in adolescents with pre-diabetes; RESIST a randomised control trial
Published in
BMC Pediatrics, November 2014
DOI 10.1186/s12887-014-0289-0
Pubmed ID
Authors

Sarah P Garnett, Megan Gow, Mandy Ho, Louise A Baur, Manny Noakes, Helen J Woodhead, Carolyn R Broderick, Kerryn Chisholm, Julie Briody, Sukanya De, Katherine Steinbeck, Shubha Srinivasan, Geoffrey R Ambler, Chris T Cowell

Abstract

BackgroundA higher protein to carbohydrate ratio in the diet may potentiate weight loss, improve body composition and cardiometabolic risk, including glucose homeostasis in adults. The aim of this randomised control trial was to determine the efficacy of two structured lifestyle interventions, differing in dietary macronutrient content, on insulin sensitivity and body composition in adolescents. We hypothesised that a moderate-carbohydrate (40-45% of energy), increased-protein (25-30%) diet would be more effective than a high-carbohydrate diet (55-60%), moderate-protein (15%) diet in improving outcomes in obese, insulin resistant adolescents.MethodsObese 10¿17 year olds with either pre-diabetes and/or clinical features of insulin resistance were recruited at two hospitals in Sydney, Australia. At baseline adolescents were prescribed metformin and randomised to one of two energy restricted diets. The intervention included regular contact with the dietician and a supervised physical activity program. Outcomes included insulin sensitivity index measured by an oral glucose tolerance test and body composition measured by dual-energy x-ray absorptiometry at 12 months.ResultsOf the 111 adolescents recruited, 85 (77%) completed the intervention. BMI expressed as a percentage of the 95th percentile decreased by 6.8% [95%CI: ¿8.8 to ¿4.9], ISI increased by 0.2 [95%CI: 0.06 to 0.39] and percent body fat decreased by 2.4% [95%CI: ¿3.4 to ¿1.3]. There were no significant differences in outcomes between diet groups at any time.ConclusionWhen treated with metformin and an exercise program, a structured, reduced energy diet, which is either high-carbohydrate or moderate-carbohydrate with increased-protein, can achieve clinically significant improvements in obese adolescents at risk of type 2 diabetes.Trial registrationAustralian New Zealand Clinical Trail Registry ACTRN12608000416392. Registered 25 August 2008.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 282 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Spain 1 <1%
Australia 1 <1%
Unknown 279 99%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 48 17%
Student > Master 43 15%
Student > Ph. D. Student 23 8%
Researcher 19 7%
Student > Doctoral Student 12 4%
Other 46 16%
Unknown 91 32%
Readers by discipline Count As %
Medicine and Dentistry 69 24%
Nursing and Health Professions 43 15%
Sports and Recreations 19 7%
Agricultural and Biological Sciences 10 4%
Psychology 8 3%
Other 35 12%
Unknown 98 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 October 2015.
All research outputs
#14,790,240
of 22,771,140 outputs
Outputs from BMC Pediatrics
#1,907
of 2,994 outputs
Outputs of similar age
#203,307
of 361,642 outputs
Outputs of similar age from BMC Pediatrics
#20
of 37 outputs
Altmetric has tracked 22,771,140 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,994 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 361,642 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 37 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.