Title |
Mutational analysis of the tyrosine kinome in serous and clear cell endometrial cancer uncovers rare somatic mutations in TNK2 and DDR1
|
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Published in |
BMC Cancer, November 2014
|
DOI | 10.1186/1471-2407-14-884 |
Pubmed ID | |
Authors |
Meghan L Rudd, Hassan Mohamed, Jessica C Price, Andrea J O’Hara, Matthieu Le Gallo, Mary Ellen Urick, Pedro Cruz, Suiyuan Zhang, Nancy F Hansen, Andrew K Godwin, Dennis C Sgroi, Tyra G Wolfsberg, James C Mullikin, Maria J Merino, Daphne W Bell |
Abstract |
Endometrial cancer (EC) is the 8th leading cause of cancer death amongst American women. Most ECs are endometrioid, serous, or clear cell carcinomas, or an admixture of histologies. Serous and clear ECs are clinically aggressive tumors for which alternative therapeutic approaches are needed. The purpose of this study was to search for somatic mutations in the tyrosine kinome of serous and clear cell ECs, because mutated kinases can point to potential therapeutic targets. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 4% |
Unknown | 23 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 5 | 21% |
Student > Ph. D. Student | 5 | 21% |
Student > Bachelor | 2 | 8% |
Student > Doctoral Student | 1 | 4% |
Other | 1 | 4% |
Other | 2 | 8% |
Unknown | 8 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 7 | 29% |
Agricultural and Biological Sciences | 4 | 17% |
Medicine and Dentistry | 2 | 8% |
Unknown | 11 | 46% |