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Mutational analysis of the tyrosine kinome in serous and clear cell endometrial cancer uncovers rare somatic mutations in TNK2 and DDR1

Overview of attention for article published in BMC Cancer, November 2014
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Title
Mutational analysis of the tyrosine kinome in serous and clear cell endometrial cancer uncovers rare somatic mutations in TNK2 and DDR1
Published in
BMC Cancer, November 2014
DOI 10.1186/1471-2407-14-884
Pubmed ID
Authors

Meghan L Rudd, Hassan Mohamed, Jessica C Price, Andrea J O’Hara, Matthieu Le Gallo, Mary Ellen Urick, Pedro Cruz, Suiyuan Zhang, Nancy F Hansen, Andrew K Godwin, Dennis C Sgroi, Tyra G Wolfsberg, James C Mullikin, Maria J Merino, Daphne W Bell

Abstract

Endometrial cancer (EC) is the 8th leading cause of cancer death amongst American women. Most ECs are endometrioid, serous, or clear cell carcinomas, or an admixture of histologies. Serous and clear ECs are clinically aggressive tumors for which alternative therapeutic approaches are needed. The purpose of this study was to search for somatic mutations in the tyrosine kinome of serous and clear cell ECs, because mutated kinases can point to potential therapeutic targets.

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Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 4%
Unknown 23 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 21%
Student > Ph. D. Student 5 21%
Student > Bachelor 2 8%
Student > Doctoral Student 1 4%
Other 1 4%
Other 2 8%
Unknown 8 33%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 7 29%
Agricultural and Biological Sciences 4 17%
Medicine and Dentistry 2 8%
Unknown 11 46%