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Viral pathogens in children hospitalized with features of central nervous system infection in a malaria-endemic region of Papua New Guinea

Overview of attention for article published in BMC Infectious Diseases, November 2014
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Title
Viral pathogens in children hospitalized with features of central nervous system infection in a malaria-endemic region of Papua New Guinea
Published in
BMC Infectious Diseases, November 2014
DOI 10.1186/s12879-014-0630-0
Pubmed ID
Authors

Moses Laman, Ilomo Hwaiwhanje, Cathy Bona, Jonathan Warrel, Susan Aipit, David Smith, Joanna Noronha, Peter Siba, Ivo Mueller, Inoni Betuela, Timothy ME Davis, Laurens Manning

Abstract

BackgroundViral central nervous system (CNS) infections are common in countries where malaria is endemic but, due to limited laboratory facilities, few studies have systematically examined the prevalence and clinical consequences of the presence of viruses in cerebrospinal fluid (CSF) from children with suspected CNS infection.MethodsWe performed a prospective study of Papua New Guinean children hospitalized with signs and symptoms of CNS infection. CSF samples from 300 children without proven bacterial/fungal meningitis were analyzed for human herpes viruses (HHV), picornaviruses, influenza, adenoviruses, flaviviruses and bacteria.ResultsFifty-five children (18%) had viral (42), bacterial (20) or both viral and bacterial (7) nucleic acids (NA) identified in their CSF. Human herpes viruses accounted for 91% of all viruses found. The identification of viral or bacterial NA was not associated with any characteristic clinical features. By contrast, malaria was associated with increased identification of viral and bacterial NA and with impaired consciousness, multiple convulsions and age. Malaria was also inversely associated with an adverse outcome. Amongst children with HHV infection, those with HHV-6 and ¿7 were younger, were more likely have impaired consciousness and had a higher proportion of adverse outcomes than children with CMV. Dengue and enteroviral infections were infrequent. Adenoviral and influenza infections were not identified.ConclusionInfections with HHV-6, HHV-7, dengue and enterovirus have the potential to cause serious CNS disease in young PNG children. However most HHVs in this malaria-endemic setting should be considered to be the result of reactivation from a latent reservoir without clinical sequelae.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Unknown 43 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 15 34%
Researcher 9 20%
Student > Bachelor 4 9%
Student > Postgraduate 4 9%
Student > Ph. D. Student 3 7%
Other 5 11%
Unknown 4 9%
Readers by discipline Count As %
Medicine and Dentistry 20 45%
Immunology and Microbiology 4 9%
Nursing and Health Professions 3 7%
Agricultural and Biological Sciences 3 7%
Biochemistry, Genetics and Molecular Biology 2 5%
Other 5 11%
Unknown 7 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 November 2014.
All research outputs
#20,243,777
of 22,771,140 outputs
Outputs from BMC Infectious Diseases
#6,459
of 7,668 outputs
Outputs of similar age
#303,090
of 361,946 outputs
Outputs of similar age from BMC Infectious Diseases
#164
of 196 outputs
Altmetric has tracked 22,771,140 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,668 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 196 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.