Title |
Short communication: timeline of radiation-induced kidney function loss after stereotactic ablative body radiotherapy of renal cell carcinoma as evaluated by serial 99mTc-DMSA SPECT/CT
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Published in |
Radiation Oncology, November 2014
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DOI | 10.1186/s13014-014-0253-z |
Pubmed ID | |
Authors |
Price Jackson, Farshad Foroudi, Daniel Pham, Michael S Hofman, Nicholas Hardcastle, Jason Callahan, Tomas Kron, Shankar Siva |
Abstract |
BackgroundStereotactic ablative body radiotherapy (SABR) has been proposed as a definitive treatment for patients with inoperable primary renal cell carcinoma. However, there is little documentation detailing the radiobiological effects of hypofractionated radiation on healthy renal tissue.FindingsIn this study we describe a methodology for assessment of regional change in renal function in response to single fraction SABR of 26Gy. In a patient with a solitary kidney, detailed follow-up of kidney function post-treatment was determined through 3-dimensional SPECT/CT imaging and 51Cr-EDTA measurements. Based on measurements of glomerular filtration rate, renal function declined rapidly by 34% at 3 months, plateaued at 43% loss at 12 months, with minimal further decrease to 49% of baseline by 18 months.ConclusionsThe pattern of renal functional change in 99mTc-DMSA uptake on SPECT/CT imaging correlates with dose delivered. This study demonstrates a dose effect relationship of SABR with loss of kidney function. |
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