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Short communication: timeline of radiation-induced kidney function loss after stereotactic ablative body radiotherapy of renal cell carcinoma as evaluated by serial 99mTc-DMSA SPECT/CT

Overview of attention for article published in Radiation Oncology, November 2014
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Title
Short communication: timeline of radiation-induced kidney function loss after stereotactic ablative body radiotherapy of renal cell carcinoma as evaluated by serial 99mTc-DMSA SPECT/CT
Published in
Radiation Oncology, November 2014
DOI 10.1186/s13014-014-0253-z
Pubmed ID
Authors

Price Jackson, Farshad Foroudi, Daniel Pham, Michael S Hofman, Nicholas Hardcastle, Jason Callahan, Tomas Kron, Shankar Siva

Abstract

BackgroundStereotactic ablative body radiotherapy (SABR) has been proposed as a definitive treatment for patients with inoperable primary renal cell carcinoma. However, there is little documentation detailing the radiobiological effects of hypofractionated radiation on healthy renal tissue.FindingsIn this study we describe a methodology for assessment of regional change in renal function in response to single fraction SABR of 26Gy. In a patient with a solitary kidney, detailed follow-up of kidney function post-treatment was determined through 3-dimensional SPECT/CT imaging and 51Cr-EDTA measurements. Based on measurements of glomerular filtration rate, renal function declined rapidly by 34% at 3 months, plateaued at 43% loss at 12 months, with minimal further decrease to 49% of baseline by 18 months.ConclusionsThe pattern of renal functional change in 99mTc-DMSA uptake on SPECT/CT imaging correlates with dose delivered. This study demonstrates a dose effect relationship of SABR with loss of kidney function.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Tunisia 1 4%
Unknown 27 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 25%
Student > Master 4 14%
Student > Ph. D. Student 2 7%
Professor > Associate Professor 2 7%
Other 2 7%
Other 4 14%
Unknown 7 25%
Readers by discipline Count As %
Medicine and Dentistry 13 46%
Engineering 2 7%
Psychology 1 4%
Physics and Astronomy 1 4%
Arts and Humanities 1 4%
Other 0 0%
Unknown 10 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 November 2014.
All research outputs
#20,243,777
of 22,771,140 outputs
Outputs from Radiation Oncology
#1,675
of 2,050 outputs
Outputs of similar age
#303,090
of 361,946 outputs
Outputs of similar age from Radiation Oncology
#67
of 85 outputs
Altmetric has tracked 22,771,140 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,050 research outputs from this source. They receive a mean Attention Score of 2.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 361,946 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 85 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.