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Phylogenetic and recombination analysis of the herpesvirus genus varicellovirus

Overview of attention for article published in BMC Genomics, November 2017
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Title
Phylogenetic and recombination analysis of the herpesvirus genus varicellovirus
Published in
BMC Genomics, November 2017
DOI 10.1186/s12864-017-4283-4
Pubmed ID
Authors

Aaron W. Kolb, Andrew C. Lewin, Ralph Moeller Trane, Gillian J. McLellan, Curtis R. Brandt

Abstract

The varicelloviruses comprise a genus within the alphaherpesvirus subfamily, and infect both humans and other mammals. Recently, next-generation sequencing has been used to generate genomic sequences of several members of the Varicellovirus genus. Here, currently available varicellovirus genomic sequences were used for phylogenetic, recombination, and genetic distance analysis. A phylogenetic network including genomic sequences of individual species, was generated and suggested a potential restriction between the ungulate and non-ungulate viruses. Intraspecies genetic distances were higher in the ungulate viruses (pseudorabies virus (SuHV-1) 1.65%, bovine herpes virus type 1 (BHV-1) 0.81%, equine herpes virus type 1 (EHV-1) 0.79%, equine herpes virus type 4 (EHV-4) 0.16%) than non-ungulate viruses (feline herpes virus type 1 (FHV-1) 0.0089%, canine herpes virus type 1 (CHV-1) 0.005%, varicella-zoster virus (VZV) 0.136%). The G + C content of the ungulate viruses was also higher (SuHV-1 73.6%, BHV-1 72.6%, EHV-1 56.6%, EHV-4 50.5%) compared to the non-ungulate viruses (FHV-1 45.8%, CHV-1 31.6%, VZV 45.8%), which suggests a possible link between G + C content and intraspecies genetic diversity. Varicellovirus clade nomenclature is variable across different species, and we propose a standardization based on genomic genetic distance. A recent study reported no recombination between sequenced FHV-1 strains, however in the present study, both splitstree, bootscan, and PHI analysis indicated recombination. We also found that the recently sequenced Brazilian CHV-1 strain BTU-1 may contain a genetic signal in the UL50 gene from an unknown varicellovirus. Together, the data contribute to a greater understanding of varicellovirus genomics, and we also suggest a new clade nomenclature scheme based on genetic distances.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 46 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 22%
Student > Doctoral Student 7 15%
Student > Bachelor 7 15%
Researcher 7 15%
Student > Master 5 11%
Other 3 7%
Unknown 7 15%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 12 26%
Biochemistry, Genetics and Molecular Biology 9 20%
Agricultural and Biological Sciences 5 11%
Immunology and Microbiology 5 11%
Arts and Humanities 3 7%
Other 5 11%
Unknown 7 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 November 2017.
All research outputs
#18,576,855
of 23,008,860 outputs
Outputs from BMC Genomics
#8,227
of 10,698 outputs
Outputs of similar age
#325,441
of 437,733 outputs
Outputs of similar age from BMC Genomics
#170
of 219 outputs
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