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The significance of ectopic crypt formation in the differential diagnosis of colorectal polyps

Overview of attention for article published in Diagnostic Pathology, November 2014
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Title
The significance of ectopic crypt formation in the differential diagnosis of colorectal polyps
Published in
Diagnostic Pathology, November 2014
DOI 10.1186/s13000-014-0212-x
Pubmed ID
Authors

Mi-Jung Kim, Eun-Jung Lee, Sung-Min Chun, Se-Jin Jang, Do Sun Kim, Doo Han Lee, Eui Gon Youk

Abstract

BackgroundEctopic crypts, defined as abnormally positioned crypts that have lost their orientation toward the muscularis mucosae, have been suggested to be the best defining histologic feature of traditional serrated adenoma (TSA). However, the significance of ectopic crypt formation (ECF) in the distinction between TSA and conventional adenoma (CA) has rarely been studied.MethodsWe designed this study to determine if ECF can be found in CA and its presence is exclusive to TSA. We studied 107 TSAs and 191 CAs including 106 tubular adenomas (TAs), 66 tubulovillous adenomas (TVAs), and 19 villous adenomas (VAs).ResultsECF was identified in most (79.4%) but not all TSAs. Additionally, ECF was not infrequent in CA (62 of 191, 32.5%), and its presence correlated with the presence of a villous component and larger tumor size (each p <0.001).ConclusionsBased on its strong association with the presence of a villous component and larger tumor size, ECF appears to be involved in the protuberant growth of colorectal CA. Because ECF can be found in CA, particularly in cases with a villous component, the possibility of CA should be considered before making a diagnosis of TSA when encountering colorectal polyps with ECF.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_212.

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Mendeley readers

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The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 15%
Student > Postgraduate 3 15%
Other 2 10%
Student > Ph. D. Student 2 10%
Student > Master 1 5%
Other 3 15%
Unknown 6 30%
Readers by discipline Count As %
Medicine and Dentistry 10 50%
Agricultural and Biological Sciences 3 15%
Computer Science 1 5%
Unknown 6 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 November 2014.
All research outputs
#15,310,749
of 22,771,140 outputs
Outputs from Diagnostic Pathology
#535
of 1,123 outputs
Outputs of similar age
#214,119
of 361,642 outputs
Outputs of similar age from Diagnostic Pathology
#30
of 54 outputs
Altmetric has tracked 22,771,140 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,123 research outputs from this source. They receive a mean Attention Score of 2.8. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 361,642 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.