Title |
Presence of early CKD-related metabolic complications predict progression of stage 3 CKD: a case-controlled study
|
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Published in |
BMC Nephrology, November 2014
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DOI | 10.1186/1471-2369-15-187 |
Pubmed ID | |
Authors |
Herbert S Chase, Jamie S Hirsch, Sumit Mohan, Maya K Rao, Jai Radhakrishnan |
Abstract |
Only a subset of patients who enter stage 3 chronic kidney disease (CKD) progress to stage 4. Identifying which patients entering stage 3 are most likely to progress could improve outcomes, by allowing more appropriate referrals for specialist care, and spare those unlikely to progress the adverse effects and costliness of an unnecessarily aggressive approach. We hypothesized that compared to non-progressors, patients who enter stage 3 CKD and ultimately progress have experienced greater loss of renal function, manifested by impairment of metabolic function (anemia, worsening acidosis and mineral abnormalities), than is reflected in the eGFR at entry to stage 3. The purpose of this case-controlled study was to design a prediction model for CKD progression using laboratory values reflecting metabolic status. |
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France | 1 | 25% |
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Unknown | 1 | 25% |
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Geographical breakdown
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