Title |
Differential gene expression and alternative splicing in insect immune specificity
|
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Published in |
BMC Genomics, November 2014
|
DOI | 10.1186/1471-2164-15-1031 |
Pubmed ID | |
Authors |
Carolyn E Riddell, Juan D Lobaton Garces, Sally Adams, Seth M Barribeau, David Twell, Eamonn B Mallon |
Abstract |
Ecological studies routinely show genotype-genotype interactions between insects and their parasites. The mechanisms behind these interactions are not clearly understood. Using the bumblebee Bombus terrestris/trypanosome Crithidia bombi model system (two bumblebee colonies by two Crithidia strains), we have carried out a transcriptome-wide analysis of gene expression and alternative splicing in bees during C. bombi infection. We have performed four analyses, 1) comparing gene expression in infected and non-infected bees 24 hours after infection by Crithidia bombi, 2) comparing expression at 24 and 48 hours after C. bombi infection, 3) determining the differential gene expression associated with the bumblebee-Crithidia genotype-genotype interaction at 24 hours after infection and 4) determining the alternative splicing associated with the bumblebee-Crithidia genotype-genotype interaction at 24 hours post infection. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 4 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 50% |
Scientists | 2 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | <1% |
Netherlands | 1 | <1% |
Austria | 1 | <1% |
Czechia | 1 | <1% |
United States | 1 | <1% |
Unknown | 116 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 37 | 31% |
Researcher | 28 | 23% |
Student > Bachelor | 13 | 11% |
Student > Master | 12 | 10% |
Student > Doctoral Student | 7 | 6% |
Other | 15 | 12% |
Unknown | 9 | 7% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 71 | 59% |
Biochemistry, Genetics and Molecular Biology | 22 | 18% |
Unspecified | 2 | 2% |
Computer Science | 2 | 2% |
Environmental Science | 1 | <1% |
Other | 7 | 6% |
Unknown | 16 | 13% |