Title |
Long-term treadmill exercise attenuates tau pathology in P301S tau transgenic mice
|
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Published in |
Molecular Neurodegeneration, November 2014
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DOI | 10.1186/1750-1326-9-54 |
Pubmed ID | |
Authors |
Odochi Ohia-Nwoko, Saghi Montazari, Yuen-Sum Lau, Jason L Eriksen |
Abstract |
Recent epidemiological evidence suggests that modifying lifestyle by increasing physical activity could be a non-pharmacological approach to improving symptoms and slowing disease progression in Alzheimer's disease and other tauopathies. Previous studies have shown that exercise reduces tau hyperphosphorylation, however, it is not known whether exercise reduces the accumulation of soluble or insoluble tau aggregates and neurofibrillary tangles, which are both neuropathological hallmarks of neurodegenerative tauopathy. In this study, 7-month old P301S tau transgenic mice were subjected to 12-weeks of forced treadmill exercise and evaluated for effects on motor function and tau pathology at 10 months of age. |
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United States | 3 | 38% |
Canada | 1 | 13% |
Italy | 1 | 13% |
Unknown | 3 | 38% |
Demographic breakdown
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Scientists | 1 | 13% |
Mendeley readers
Geographical breakdown
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Unknown | 106 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 18 | 17% |
Student > Bachelor | 18 | 17% |
Student > Ph. D. Student | 17 | 16% |
Student > Doctoral Student | 12 | 11% |
Researcher | 7 | 7% |
Other | 16 | 15% |
Unknown | 19 | 18% |
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Sports and Recreations | 7 | 7% |
Other | 24 | 22% |
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