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Highly pathogenic avian influenza virus infection in chickens but not ducks is associated with elevated host immune and pro-inflammatory responses

Overview of attention for article published in Veterinary Research, November 2014
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Mentioned by

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2 tweeters
facebook
1 Facebook page

Citations

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64 Dimensions

Readers on

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65 Mendeley
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Title
Highly pathogenic avian influenza virus infection in chickens but not ducks is associated with elevated host immune and pro-inflammatory responses
Published in
Veterinary Research, November 2014
DOI 10.1186/s13567-014-0118-3
Pubmed ID
Authors

Suresh V Kuchipudi, Meenu Tellabati, Sujith Sebastian, Brandon Z Londt, Christine Jansen, Lonneke Vervelde, Sharon M Brookes, Ian H Brown, Stephen P Dunham, Kin-Chow Chang

Abstract

Highly pathogenic avian influenza (HPAI) H5N1 viruses cause severe infection in chickens at near complete mortality, but corresponding infection in ducks is typically mild or asymptomatic. To understand the underlying molecular differences in host response, primary chicken and duck lung cells, infected with two HPAI H5N1 viruses and a low pathogenicity avian influenza (LPAI) H2N3 virus, were subjected to RNA expression profiling. Chicken cells but not duck cells showed highly elevated immune and pro-inflammatory responses following HPAI virus infection. HPAI H5N1 virus challenge studies in chickens and ducks corroborated the in vitro findings. To try to determine the underlying mechanisms, we investigated the role of signal transducer and activator of transcription-3 (STAT-3) in mediating pro-inflammatory response to HPAIV infection in chicken and duck cells. We found that STAT-3 expression was down-regulated in chickens but was up-regulated or unaffected in ducks in vitro and in vivo following H5N1 virus infection. Low basal STAT-3 expression in chicken cells was completely inhibited by H5N1 virus infection. By contrast, constitutively active STAT-3 detected in duck cells was unaffected by H5N1 virus infection. Transient constitutively-active STAT-3 transfection in chicken cells significantly reduced pro-inflammatory response to H5N1 virus infection; on the other hand, chemical inhibition of STAT-3 activation in duck cells increased pro-inflammatory gene expression following H5N1 virus infection. Collectively, we propose that elevated pro-inflammatory response in chickens is a major pathogenicity factor of HPAI H5N1 virus infection, mediated in part by the inhibition of STAT-3.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 3%
Poland 1 2%
Denmark 1 2%
Canada 1 2%
Unknown 60 92%

Demographic breakdown

Readers by professional status Count As %
Researcher 16 25%
Student > Ph. D. Student 14 22%
Student > Master 8 12%
Student > Bachelor 6 9%
Professor 4 6%
Other 9 14%
Unknown 8 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 30 46%
Immunology and Microbiology 9 14%
Veterinary Science and Veterinary Medicine 8 12%
Medicine and Dentistry 3 5%
Biochemistry, Genetics and Molecular Biology 2 3%
Other 4 6%
Unknown 9 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 December 2017.
All research outputs
#9,985,199
of 15,677,517 outputs
Outputs from Veterinary Research
#590
of 948 outputs
Outputs of similar age
#162,010
of 306,918 outputs
Outputs of similar age from Veterinary Research
#38
of 62 outputs
Altmetric has tracked 15,677,517 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 948 research outputs from this source. They receive a mean Attention Score of 4.2. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 306,918 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 62 others from the same source and published within six weeks on either side of this one. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.