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Pregnancy complications in acquired thrombotic thrombocytopenic purpura: a case–control study

Overview of attention for article published in Orphanet Journal of Rare Diseases, November 2014
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Title
Pregnancy complications in acquired thrombotic thrombocytopenic purpura: a case–control study
Published in
Orphanet Journal of Rare Diseases, November 2014
DOI 10.1186/s13023-014-0193-6
Pubmed ID
Authors

Barbara Ferrari, Alberto Maino, Luca A Lotta, Andrea Artoni, Silvia Pontiggia, Silvia M Trisolini, Alessandra Malato, Frits R Rosendaal, Flora Peyvandi

Abstract

BackgroundPregnant women with a history of acquired thrombotic thrombocytopenic purpura (TTP) are considered at risk for disease recurrence and might be at risk for miscarriage, similar to other autoimmune disorders. However, the exact entity of these risks and their causes are unknown. The aim of this study was to evaluate risk factors associated with adverse pregnancy outcome, in terms of both gravidic TTP and miscarriage, in women affected by previous acquired TTP.MethodsWe conducted a nested case¿control study in women with a history of acquired TTP enrolled in the Milan TTP registry from 1994 to October 2012, with strict inclusion criteria to reduce referral and selection bias.ResultsFifteen out of 254 women with acquired TTP were included, namely four cases with gravidic TTP, five with miscarriage, and six controls with uncomplicated pregnancy. In the cases, ADAMTS13 activity levels in the first trimester were moderately-to-severely reduced (median levels <3% in gravidic TTP and median levels 20% [range 14-40%] in the women with miscarriage) and anti-ADAMTS13 antibodies were invariably present, while in the control group ADAMTS13 activity levels were normal (median 90%, range 40-129%), with absence of detectable anti-ADAMTS13 antibodies. Reduced levels of ADAMTS13 activity (<25%) in the first trimester were associated with an over 2.9-fold increased risk for gravidic TTP and with an over 1.2-fold increased risk for miscarriage (lower boundary of the confidence interval of the odds ratio). In addition, the presence of anti-ADAMTS13 antibodies during pregnancy was associated with an over 6.6-fold increased risk for gravidic TTP and with an over 4.1-fold increased risk for miscarriage.ConclusionsADAMTS13 activity evaluation and detection of anti-ADAMTS13 antibody could help to predict the risk of complications in pregnant women with a history of acquired TTP.

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The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Ethiopia 1 4%
Unknown 23 96%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 21%
Researcher 5 21%
Student > Postgraduate 3 13%
Student > Bachelor 3 13%
Other 2 8%
Other 3 13%
Unknown 3 13%
Readers by discipline Count As %
Medicine and Dentistry 14 58%
Biochemistry, Genetics and Molecular Biology 2 8%
Agricultural and Biological Sciences 2 8%
Social Sciences 1 4%
Nursing and Health Professions 1 4%
Other 0 0%
Unknown 4 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 January 2016.
All research outputs
#4,993,819
of 7,012,411 outputs
Outputs from Orphanet Journal of Rare Diseases
#749
of 1,011 outputs
Outputs of similar age
#136,366
of 229,769 outputs
Outputs of similar age from Orphanet Journal of Rare Diseases
#46
of 72 outputs
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