Title |
Diversity-oriented synthesis and activity evaluation of substituted bicyclic lactams as anti-malarial against Plasmodium falciparum
|
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Published in |
Malaria Journal, November 2014
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DOI | 10.1186/1475-2875-13-467 |
Pubmed ID | |
Authors |
Vijeta Sharma, Shalini Agarwal, Sanjay M Madurkar, Gaurav Datta, Poonam Dangi, Ramu Dandugudumula, Subhabrata Sen, Shailja Singh |
Abstract |
Malaria remains the world's most important devastating parasitic disease. Of the five species of Plasmodium known to infect and cause human malaria, Plasmodium falciparum is the most virulent and responsible for majority of the deaths caused by this disease. Mainstream drug therapy targets the asexual blood stage of the malaria parasite, as the disease symptoms are mainly associated with this stage. The prevalence of malaria parasite strains resistance to existing anti-malarial drugs has made the control of malaria even more challenging and hence the development of a new class of drugs is inevitable. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 4% |
Burkina Faso | 1 | 4% |
Unknown | 24 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 8 | 31% |
Researcher | 5 | 19% |
Student > Bachelor | 3 | 12% |
Lecturer | 1 | 4% |
Student > Doctoral Student | 1 | 4% |
Other | 4 | 15% |
Unknown | 4 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 6 | 23% |
Medicine and Dentistry | 5 | 19% |
Biochemistry, Genetics and Molecular Biology | 4 | 15% |
Chemistry | 4 | 15% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 8% |
Other | 0 | 0% |
Unknown | 5 | 19% |