Title |
Boosting Wnt activity during colorectal cancer progression through selective hypermethylation of Wnt signaling antagonists
|
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Published in |
BMC Cancer, November 2014
|
DOI | 10.1186/1471-2407-14-891 |
Pubmed ID | |
Authors |
Ana-Luisa Silva, Sarah N Dawson, Mark J Arends, Kiran Guttula, Nigel Hall, Ewen A Cameron, Tim H-M Huang, James D Brenton, Simon Tavaré, Mariann Bienz, Ashraf EK Ibrahim |
Abstract |
There is emerging evidence that Wnt pathway activity may increase during the progression from colorectal adenoma to carcinoma and that this increase is potentially an important step towards the invasive stage. Here, we investigated whether epigenetic silencing of Wnt antagonists is the biological driver for this increased Wnt activity in human tissues and how these methylation changes correlate with MSI (Microsatelite Instability) and CIMP (CpG Island Methylator Phenotype) statuses as well as known mutations in genes driving colorectal neoplasia. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Germany | 1 | 1% |
Brazil | 1 | 1% |
Unknown | 66 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 17 | 25% |
Researcher | 12 | 18% |
Student > Master | 7 | 10% |
Student > Bachelor | 6 | 9% |
Other | 6 | 9% |
Other | 7 | 10% |
Unknown | 13 | 19% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 22 | 32% |
Agricultural and Biological Sciences | 12 | 18% |
Medicine and Dentistry | 11 | 16% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
Immunology and Microbiology | 3 | 4% |
Other | 3 | 4% |
Unknown | 14 | 21% |