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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Systematic review of management for treatment-resistant depression in adolescents
|
|---|---|
| Published in |
BMC Psychiatry, November 2014
|
| DOI | 10.1186/s12888-014-0340-6 |
| Pubmed ID | |
| Authors |
Xinyu Zhou, Kurt D Michael, Yiyun Liu, Cinzia Del Giovane, Bin Qin, David Cohen, Salvatore Gentile, Peng Xie |
| Abstract |
BackgroundCurrent guidelines for treatment-resistant depression in adolescents remain inadequate. This study aimed to systematically review the management of treatment-resistant depression in adolescent patients.MethodsWe conducted an electronic database search of PUBMED, EMBASE, Cochrane, Web of Science and PsycINFO for studies with adolescent treatment-resistant depression published up to January 2014. Treatment-resistant depression was defined as failure to respond to at least one course of psychological or pharmacological treatment for depression with an adequate dosage, duration, and appropriate compliance during the current illness episode. The Cochrane risk-of-bias method was used to assess the quality of randomized controlled trials. A meta-analysis of all active treatments was conducted.ResultsEight studies with 411 depressed adolescents that fit predetermined criteria investigated pharmacological treatments and psychotherapies. Six were open-label studies, and two were randomized controlled trials. The overall response rate for all active treatments investigated was 46% (95% CI 33 to 59; N¿=¿411) with a moderately high degree of heterogeneity (I2¿=¿76.1%, 95% CI¿=¿47%-86%). When only the two randomized trials were included, the overall response rate of active treatment was 53% (95% CI¿=¿38-67; N¿=¿347). In these randomized trials, SSRI therapy plus CBT was significantly more effective than SSRI therapy alone, while amitriptyline was not more effective than placebo.ConclusionsApproximately half of the adolescents who presented with treatment-refractory depression responded to active treatment, which suggests that practitioners should remain persistent in managing these challenging cases. The combination of antidepressant medication and psychotherapy should be recommended for adolescents who present with treatment-resistant depression. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 179 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Sweden | 1 | <1% |
| Unknown | 177 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 28 | 16% |
| Student > Bachelor | 27 | 15% |
| Researcher | 22 | 12% |
| Student > Ph. D. Student | 16 | 9% |
| Other | 12 | 7% |
| Other | 28 | 16% |
| Unknown | 46 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 41 | 23% |
| Psychology | 36 | 20% |
| Neuroscience | 10 | 6% |
| Nursing and Health Professions | 7 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 3% |
| Other | 27 | 15% |
| Unknown | 53 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 January 2024.
All research outputs
#4,894,961
of 25,837,817 outputs
Outputs from BMC Psychiatry
#1,999
of 5,507 outputs
Outputs of similar age
#62,856
of 374,009 outputs
Outputs of similar age from BMC Psychiatry
#21
of 91 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,507 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.4. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 374,009 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 91 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.