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Effects of differences in serum total homocysteine, folate, and vitamin B12on cognitive impairment in stroke patients

Overview of attention for article published in BMC Neurology, November 2014
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Title
Effects of differences in serum total homocysteine, folate, and vitamin B12on cognitive impairment in stroke patients
Published in
BMC Neurology, November 2014
DOI 10.1186/s12883-014-0217-9
Pubmed ID
Authors

Bo Jiang, Yumei Chen, Guoen Yao, Cunshan Yao, Hongmei Zhao, Xiangdong Jia, Yunyan Zhang, Junling Ge, Enchao Qiu, Chengyun Ding

Abstract

BackgroundVascular cognitive impairment-no dementia (VCIND) refers to the early or mild cognitive impairment induced by cerebral vascular injury. Research shows that serum total homocysteine (tHcy) level is an independent risk factor for cerebral vascular disease and may be closely related to cognitive function.Current studies on the tHcy level in VCIND patients are limited, and the relationship of tHcy with cognitive function remains unclear. This study aims to investigate the tHcy levels in patients with VCIND and to determine their correlation with cognitive function, as well as to provide useful clues for preventing and treating VCIND.MethodsThe tHcy, folate, and vitamin B12 levels in 82 patients with VCIND were reviewed retrospectively and compared with those of 80 stroke patients without cognitive impairment and 69 healthy controls by using the Montreal Cognitive Assessment (MoCA) scale and the event-related potential P300 to evaluate cognitive function.ResultsThe tHcy levels in the VCIND group were higher than those in the other two groups, whereas the folate and Vitamin B12 levels in the VCIND group were lower than those of the other two groups. The tHcy levels in the stroke group were higher than those in the control group, and the folate and vitamin B12 levels in the stroke group were lower than those in the control group. The patients in the VCIND group with high tHcy exhibited lower MoCA scores and prolonged P300 latency than those in with normal tHcy. Correlation analysis showed that tHcy level is positively correlated with P300 latency period and negatively correlated with MoCA score.ConclusionThe tHcy levels were significantly higher and the vitamin B12 and folate levels were significantly lower in the patients with VCIND than those in the other groups. The high tHcy levels in the VCIND patients may be correlated with impaired cognitive function.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Canada 1 1%
Unknown 65 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 12 18%
Student > Ph. D. Student 11 16%
Researcher 10 15%
Student > Postgraduate 4 6%
Student > Doctoral Student 4 6%
Other 13 19%
Unknown 13 19%
Readers by discipline Count As %
Medicine and Dentistry 22 33%
Psychology 8 12%
Neuroscience 6 9%
Nursing and Health Professions 4 6%
Agricultural and Biological Sciences 3 4%
Other 9 13%
Unknown 15 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 December 2014.
All research outputs
#18,385,510
of 22,772,779 outputs
Outputs from BMC Neurology
#1,882
of 2,428 outputs
Outputs of similar age
#261,785
of 361,296 outputs
Outputs of similar age from BMC Neurology
#19
of 26 outputs
Altmetric has tracked 22,772,779 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,428 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
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We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.