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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Do patients with very few brain metastases from breast cancer benefit from whole-brain radiotherapy in addition to radiosurgery?
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|---|---|
| Published in |
Radiation Oncology, December 2014
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| DOI | 10.1186/s13014-014-0267-6 |
| Pubmed ID | |
| Authors |
Dirk Rades, Stefan Huttenlocher, Dagmar Hornung, Oliver Blanck, Steven E Schild, Dorothea Fischer |
| Abstract |
BackgroundAn important issue in palliative radiation oncology is the whether whole-brain radiotherapy should be added to radiosurgery when treating a limited number of brain metastases. To optimize personalized treatment of cancer patients with brain metastases, the value of whole-brain radiotherapy should be described separately for each tumor entity. This study investigated the role of whole-brain radiotherapy added to radiosurgery in breast cancer patients.MethodsFifty-eight patients with 1¿3 brain metastases from breast cancer were included in this retrospective study. Of these patients, 30 were treated with radiosurgery alone and 28 with radiosurgery plus whole-brain radiotherapy. Both groups were compared for local control of the irradiated metastases, freedom from new brain metastases and survival. Furthermore, eight additional factors were analyzed including dose of radiosurgery, age at radiotherapy, Eastern Cooperative Oncology Group (ECOG) performance score, number of brain metastases, maximum diameter of all brain metastases, site of brain metastases, extra-cranial metastases and the time from breast cancer diagnosis to radiotherapy.ResultsThe treatment regimen had no significant impact on local control in the univariate analysis (p¿=¿0.59). Age ¿59 years showed a trend towards improved local control on univariate (p¿=¿0.066) and multivariate analysis (p¿=¿0.07). On univariate analysis, radiosurgery plus whole-brain radiotherapy (p¿=¿0.040) and ECOG 0¿1 (p¿=¿0.012) showed positive associations with freedom from new brain metastases. Both treatment regimen (p¿=¿0.039) and performance status (p¿=¿0.028) maintained significance on multivariate analysis. ECOG 0¿1 was positively correlated with survival on univariate analysis (p¿<¿0.001); age ¿59 years showed a strong trend (p¿=¿0.054). On multivariate analysis, performance status (p¿<¿0.001) and age (p¿=¿0.041) were significant.ConclusionsIn breast cancer patients with few brain metastases, radiosurgery plus whole-brain radiotherapy resulted in significantly better freedom from new brain metastases than radiosurgery alone. However, this advantage did not lead to significantly better survival. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Slovenia | 1 | 3% |
| Unknown | 30 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 6 | 19% |
| Student > Bachelor | 5 | 16% |
| Student > Ph. D. Student | 4 | 13% |
| Other | 3 | 10% |
| Student > Postgraduate | 3 | 10% |
| Other | 3 | 10% |
| Unknown | 7 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 11 | 35% |
| Biochemistry, Genetics and Molecular Biology | 3 | 10% |
| Agricultural and Biological Sciences | 3 | 10% |
| Physics and Astronomy | 1 | 3% |
| Social Sciences | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 11 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 December 2014.
All research outputs
#18,385,510
of 22,772,779 outputs
Outputs from Radiation Oncology
#1,409
of 2,050 outputs
Outputs of similar age
#261,280
of 360,768 outputs
Outputs of similar age from Radiation Oncology
#53
of 85 outputs
Altmetric has tracked 22,772,779 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,050 research outputs from this source. They receive a mean Attention Score of 2.7. This one is in the 18th percentile – i.e., 18% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 360,768 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 85 others from the same source and published within six weeks on either side of this one. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.