Title |
MicroRNA miR-320a and miR-140 inhibit mink enteritis virus infection by repression of its receptor, feline transferrin receptor
|
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Published in |
Virology Journal, December 2014
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DOI | 10.1186/s12985-014-0210-3 |
Pubmed ID | |
Authors |
Jia-zeng Sun, Jigui Wang, Shuang Wang, Daoli Yuan, Zhili Li, Bao Yi, Qiang Hou, Yaping Mao, Weiquan Liu |
Abstract |
Mink enteritis virus (MEV) is one of the most important pathogens in the mink industry. Recent studies have shed light into the role of microRNAs (miRNAs), small noncoding RNAs of length ranging from 18¿23 nucleotides (nt), as critical modulators in the host-pathogen interaction networks. We previously showed that miRNA miR-181b can inhibit MEV replication by repression of viral non-structural protein 1 expression. Here, we report that two other miRNAs (miR-320a and miR-140) inhibit MEV entry into feline kidney (F81) cells by downregulating its receptor, transferrin receptor (TfR), by targeting the 3¿ untranslated region (UTR) of TfR mRNA, while being themselves upregulated. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 4 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 75% |
Science communicators (journalists, bloggers, editors) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 12 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 3 | 25% |
Researcher | 3 | 25% |
Student > Master | 2 | 17% |
Student > Bachelor | 1 | 8% |
Other | 1 | 8% |
Other | 1 | 8% |
Unknown | 1 | 8% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 4 | 33% |
Biochemistry, Genetics and Molecular Biology | 3 | 25% |
Veterinary Science and Veterinary Medicine | 2 | 17% |
Nursing and Health Professions | 1 | 8% |
Computer Science | 1 | 8% |
Other | 0 | 0% |
Unknown | 1 | 8% |