Title |
Limited polymorphisms in k13 gene in Plasmodium falciparum isolates from Dakar, Senegal in 2012–2013
|
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Published in |
Malaria Journal, December 2014
|
DOI | 10.1186/1475-2875-13-472 |
Pubmed ID | |
Authors |
Marylin Torrentino-Madamet, Bécaye Fall, Nicolas Benoit, Cheikhou Camara, Rémy Amalvict, Mansour Fall, Pierre Dionne, Kadidiatou Ba Fall, Aminata Nakoulima, Bakary Diatta, Yaya Diemé, Didier Ménard, Boubacar Wade, Bruno Pradines |
Abstract |
The emergence of Plasmodium falciparum resistance to artemisinin and its derivatives, manifested as delayed parasite clearance following the treatment, has developed in Southeast Asia. The spread of resistance to artemisinin from Asia to Africa may be catastrophic for malaria control and elimination worldwide. Recently, mutations in the propeller domain of the Kelch 13 (k13) gene (PF3D71343700) were associated with in vitro resistance to artemisinin and with delayed clearance after artemisinin treatment in southern Asia. The aim of the study was to characterize the genetic variability of k13 and to evaluate the molecular resistance to artemisinin for the first time in Senegal. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 1% |
Burkina Faso | 1 | <1% |
Unknown | 145 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 31 | 21% |
Student > Master | 28 | 19% |
Researcher | 25 | 17% |
Student > Bachelor | 13 | 9% |
Student > Doctoral Student | 9 | 6% |
Other | 25 | 17% |
Unknown | 17 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 42 | 28% |
Biochemistry, Genetics and Molecular Biology | 36 | 24% |
Medicine and Dentistry | 24 | 16% |
Immunology and Microbiology | 5 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 3% |
Other | 14 | 9% |
Unknown | 23 | 16% |