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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Triple combination antibiotic therapy for carbapenemase-producing Klebsiella pneumoniae: a systematic review
|
|---|---|
| Published in |
Annals of Clinical Microbiology and Antimicrobials, November 2017
|
| DOI | 10.1186/s12941-017-0249-2 |
| Pubmed ID | |
| Authors |
David M. Jacobs, M. Courtney Safir, Dennis Huang, Faisal Minhaj, Adam Parker, Gauri G. Rao |
| Abstract |
The spread of carbapenemase-producing K. pneumoniae (CPKP) has become a significant problem worldwide. Combination therapy for CPKP is encouraging, but polymyxin resistance to many antibiotics is hampering effective treatment. Combination therapy with three or more antibiotics is being increasingly reported, therefore we performed a systematic review of triple combination cases in an effort to evaluate their clinical effectiveness for CPKP infections. The PubMed database was searched to identify all published clinical outcomes of CPKP infections treated with triple combination therapy. Articles were stratified into two tiers depending on the level of clinical detail provided. A tier 1 study included: antibiotic regimen, regimen-specific outcome, patient status at onset of infection, and source of infection. Articles not reaching these criteria were considered tier 2. Thirty-three studies were eligible, 23 tier 1 and ten tier 2. Among tier 1 studies, 53 cases were included in this analysis. The most common infection was pneumonia (31%) followed by primary or catheter-related bacteremia (21%) and urinary tract infection (17%). Different combinations of antibiotic classes were utilized in triple combinations, the most common being a polymyxin (colistin or polymyxin B, 86.8%), tigecycline (73.6%), aminoglycoside (43.4%), or carbapenem (43.4%). Clinical and microbiological failure occurred in 14/39 patients (35.9%) and 22/42 patients (52.4%), respectively. Overall mortality for patients treated with triple combination therapy was 35.8% (19/53 patients). Triple combination therapy is being considered as a treatment option for CPKP. Polymyxin-based therapy is the backbone antibiotic in these regimens, but its effectiveness needs establishing in prospective clinical trials. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Venezuela, Bolivarian Republic of | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 127 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 127 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 15 | 12% |
| Researcher | 13 | 10% |
| Student > Bachelor | 13 | 10% |
| Other | 10 | 8% |
| Student > Ph. D. Student | 9 | 7% |
| Other | 22 | 17% |
| Unknown | 45 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 31 | 24% |
| Pharmacology, Toxicology and Pharmaceutical Science | 12 | 9% |
| Biochemistry, Genetics and Molecular Biology | 11 | 9% |
| Immunology and Microbiology | 7 | 6% |
| Agricultural and Biological Sciences | 4 | 3% |
| Other | 13 | 10% |
| Unknown | 49 | 39% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 December 2017.
All research outputs
#14,959,314
of 23,008,860 outputs
Outputs from Annals of Clinical Microbiology and Antimicrobials
#315
of 611 outputs
Outputs of similar age
#251,302
of 438,185 outputs
Outputs of similar age from Annals of Clinical Microbiology and Antimicrobials
#6
of 9 outputs
Altmetric has tracked 23,008,860 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 611 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 438,185 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.