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Increased constitutive αSMA and Smad2/3 expression in idiopathic pulmonary fibrosis myofibroblasts is KCa3.1-dependent

Overview of attention for article published in Respiratory Research, December 2014
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Title
Increased constitutive αSMA and Smad2/3 expression in idiopathic pulmonary fibrosis myofibroblasts is KCa3.1-dependent
Published in
Respiratory Research, December 2014
DOI 10.1186/s12931-014-0155-5
Pubmed ID
Authors

Katy M Roach, Heike Wulff, Carol Feghali-Bostwick, Yassine Amrani, Peter Bradding

Abstract

Idiopathic pulmonary fibrosis is a common and invariably fatal disease with limited therapeutic options. Ca2+-activated KCa3.1 potassium channels play a key role in promoting TGFβ1 and bFGF-dependent profibrotic responses in human lung myofibroblasts (HLMFs). We hypothesised that KCa3.1 channel-dependent cell processes regulate HLMF αSMA expression via Smad2/3 signalling pathways.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 29 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 21%
Researcher 5 17%
Student > Bachelor 3 10%
Student > Ph. D. Student 3 10%
Professor 2 7%
Other 4 14%
Unknown 6 21%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 7 24%
Medicine and Dentistry 6 21%
Psychology 4 14%
Physics and Astronomy 1 3%
Nursing and Health Professions 1 3%
Other 2 7%
Unknown 8 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 December 2014.
All research outputs
#15,170,530
of 25,377,790 outputs
Outputs from Respiratory Research
#1,601
of 3,062 outputs
Outputs of similar age
#191,507
of 367,059 outputs
Outputs of similar age from Respiratory Research
#31
of 38 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. This one is in the 38th percentile – i.e., 38% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,062 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.9. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 367,059 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 38 others from the same source and published within six weeks on either side of this one. This one is in the 5th percentile – i.e., 5% of its contemporaries scored the same or lower than it.