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Humanized HLA-DR4.RagKO.IL2RγcKO.NOD (DRAG) mice sustain the complex vertebrate life cycle of Plasmodium falciparum malaria

Overview of attention for article published in Malaria Journal, September 2014
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Citations

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73 Mendeley
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Title
Humanized HLA-DR4.RagKO.IL2RγcKO.NOD (DRAG) mice sustain the complex vertebrate life cycle of Plasmodium falciparum malaria
Published in
Malaria Journal, September 2014
DOI 10.1186/1475-2875-13-386
Pubmed ID
Authors

Wathsala Wijayalath, Sai Majji, Eileen F Villasante, Teodor D Brumeanu, Thomas L Richie, Sofia Casares

Abstract

Malaria is a deadly infectious disease affecting millions of people in tropical and sub-tropical countries. Among the five species of Plasmodium parasites that infect humans, Plasmodium falciparum accounts for the highest morbidity and mortality associated with malaria. Since humans are the only natural hosts for P. falciparum, the lack of convenient animal models has hindered the understanding of disease pathogenesis and prompted the need of testing anti-malarial drugs and vaccines directly in human trials. Humanized mice hosting human cells represent new pre-clinical models for infectious diseases that affect only humans. In this study, the ability of human-immune-system humanized HLA-DR4.RagKO.IL2RγcKO.NOD (DRAG) mice to sustain infection with P. falciparum was explored.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Unknown 72 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 17 23%
Student > Ph. D. Student 13 18%
Student > Master 10 14%
Student > Bachelor 7 10%
Lecturer 3 4%
Other 11 15%
Unknown 12 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 20 27%
Biochemistry, Genetics and Molecular Biology 10 14%
Immunology and Microbiology 10 14%
Medicine and Dentistry 8 11%
Pharmacology, Toxicology and Pharmaceutical Science 3 4%
Other 8 11%
Unknown 14 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 December 2014.
All research outputs
#20,245,139
of 22,772,779 outputs
Outputs from Malaria Journal
#5,317
of 5,555 outputs
Outputs of similar age
#211,215
of 252,706 outputs
Outputs of similar age from Malaria Journal
#80
of 92 outputs
Altmetric has tracked 22,772,779 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,555 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 252,706 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 92 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.