Title |
Humanized HLA-DR4.RagKO.IL2RγcKO.NOD (DRAG) mice sustain the complex vertebrate life cycle of Plasmodium falciparum malaria
|
---|---|
Published in |
Malaria Journal, September 2014
|
DOI | 10.1186/1475-2875-13-386 |
Pubmed ID | |
Authors |
Wathsala Wijayalath, Sai Majji, Eileen F Villasante, Teodor D Brumeanu, Thomas L Richie, Sofia Casares |
Abstract |
Malaria is a deadly infectious disease affecting millions of people in tropical and sub-tropical countries. Among the five species of Plasmodium parasites that infect humans, Plasmodium falciparum accounts for the highest morbidity and mortality associated with malaria. Since humans are the only natural hosts for P. falciparum, the lack of convenient animal models has hindered the understanding of disease pathogenesis and prompted the need of testing anti-malarial drugs and vaccines directly in human trials. Humanized mice hosting human cells represent new pre-clinical models for infectious diseases that affect only humans. In this study, the ability of human-immune-system humanized HLA-DR4.RagKO.IL2RγcKO.NOD (DRAG) mice to sustain infection with P. falciparum was explored. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 1% |
Unknown | 72 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 17 | 23% |
Student > Ph. D. Student | 13 | 18% |
Student > Master | 10 | 14% |
Student > Bachelor | 7 | 10% |
Lecturer | 3 | 4% |
Other | 11 | 15% |
Unknown | 12 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 20 | 27% |
Biochemistry, Genetics and Molecular Biology | 10 | 14% |
Immunology and Microbiology | 10 | 14% |
Medicine and Dentistry | 8 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
Other | 8 | 11% |
Unknown | 14 | 19% |